OBJECTIVE Insulin-like growth factor I (IGF-1) stimulates cardiac growth and contraction, but resistance to its action has been reported in diabetes. This study was to determine if IGF-1-induced cardiac contractile action is altered in rats genetically predisposed to diabetes. METHOD Ventricular myocytes were isolated from spontaneously biobreeding diabetes-prone (BB/DP) rats and their diabet...

PURPOSE To investigate the functional properties and intracellular signaling of hyalocytes under platelet-derived growth factor (PDGF)-rich conditions. METHODS The hyalocytes were isolated from bovine eyes and identified by immunocytochemistry and electron microscope. The expression of PDGF receptor alpha/beta and its phosphorylation in response to PDGF-BB was analyzed by Western blot analysi...

OBJECTIVE Impaired gastric accommodation is reported in patients with functional dyspepsia (FD). Previous findings in postinfectious patients with FD suggest that low-grade inflammation and dysfunction of nitrergic nerves play a role in impaired accommodation. To date, spontaneous animal models to study the relationship between these changes are lacking. We hypothesise that the normoglycaemic B...

Benzylideneacetophenone analogues are known to have several significant biological activities, including antiinflammatory, antitumor, antibacterial, antiviral, and gastric-protective activities. However, the antiproliferative effects of benzylideneacetophenone analogues on vascular smooth muscle cells (VSMCs) are unknown. The aim of this study was to elucidate the antiproliferative effects and ...

Background and aim A possible aetiological connection between skin sclerosis and infection with Borrelia burgdorferi (Bb) has been discussed. Studies investigating the link between Bb and morphea have produced conflicting results. In several series, all patients with morphea tested have been seronegative. Other studies have found specific antibodies to Bb in between 6% and 54% of patients with ...

Abstract The impact of using chemical fertilizers in the cultivation system changes soil’s physicochemical characteristics. Local resources-based amelioration technology can be used as a solution to increase soil fertility and plant productivity. This study aimed measure properties Inceptisols monoculture polyculture systems. A randomized block design was this research with eight treatments thr...

Arabica coffee is a type of that widely grown in the highlands North Sumatra. Siborongborong District largest producing. However, productivity lower than potential sigararutang variety. This study aims to analyse effect fertilizer, Beauveria bassiana (Bb) and labour use on production compare income farmers who Bb intensively, non - intensively do not Bb. The method used are multiple linear regr...

The purpose of this experiment was to determine the antidiabetic and lipid-lowering effects of (-)-epicatechin-3-O-β-D-allopyranoside (BB) from the roots and stems of Davallia formosana in mice. Animal treatment was induced by high-fat diet (HFD) or low-fat diet (control diet, CD). After eight weeks of HFD or CD exposure, the HFD mice were treating with BB or rosiglitazone (Rosi) or fenofibrate...

BACKGROUND/OBJECTIVES Artemisinin (AT), an active compound in Arternisia annua, is well known as an anti-malaria drug. It is also known to have several effects including anti-oxidant, anti-inflammation, and anti-cancer activities. To date, the effect of AT on vascular disorders has not been studied. In this study, we investigated the effects of AT on the migration and proliferation of vascular ...

27 This study investigated whether repetitive transcranial magnetic stimulation (TMS) delivered as 28 continuous theta burst stimulation (cTBS) to left M1 degraded selective muscle activation in the 29 contralateral and ipsilateral upper limb in healthy participants. Contralateral motor evoked 30 potentials (cMEPs) were elicited in left and right biceps brachii (BB) before either elbow flexion ...