In the present study we demonstrate that human monocytes can be induced by the model stimulus, lipopolysaccharide (LPS), to produce and assemble on their surface functional Factor VII/VIIa. This protease was not induced in relatively purified monocytes alone following exposure to LPS; but was induced in the presence of Leu-3a positive helper/inducer T cells. The Factor VII/VIIa protease activit...

The cytotoxicity of several important antitumor drugs depends on formation of the covalent topoisomerase-DNA cleavage complex. However, cellular processes such as DNA replication are necessary to convert the cleavage complex into a cytotoxic lesion, but the molecular mechanism of this conversion and the precise nature of the cytotoxic lesion are unknown. Using a bacteriophage T4 model system, w...

In total, 59 single Cys-replacement mutants in helix VII and helix X of the lactose permease of Escherichia coli were subjected to site-directed fluorescence labeling in right-side-out membrane vesicles to complete the testing of Cys accessibility or reactivity. For both helices, accessibility/reactivity is relatively low at the level of the sugar-binding site where the helices are tightly pack...

This study aims to determine the effect of Everyday Mathematics (EM) Learning Model on Students' Critical and Creative Thinking Ability. type research uses Quasi Experiment method. Data collection is done through tests. analysis used Ancova test. The sample this students SMPN 01 Lebong class VII.4 VII.6. results showed that: There a linear influence initial ability covariates students' critical...

Syt VII is a Ca(2+) sensor that regulates lysosome exocytosis and plasma membrane repair. Because it lacks motifs that mediate lysosomal targeting, it is unclear how Syt VII traffics to these organelles. In this paper, we show that mutations or inhibitors that abolish palmitoylation disrupt Syt VII targeting to lysosomes, causing its retention in the Golgi complex. In macrophages, Syt VII is tr...

This document is partly based on Chapter III of "Dynamics and Modelling of Ocean Waves" by Komen et al, 1994. For more background information on the fundamentals of wave prediction models this book comes highly recommended. Here, after a historical introduction, we will describe the basic evolution equation, including a discussion of the parametrization of the source functions. This is then fol...

A novel imaging process, referred to as vector image isochron (VII) migration, is specifically designed to reduce artifacts caused by arrays with limited apertures. By examining the assumptions behind generalized Radon transform (GRT) migration, a new approach is found which identifies and suppresses array artifacts, based on the array geometry and the migration earth model. The new method work...

A generic broker agent architecture is introduced, designed in a principled manner using the compositional development method for multi-agent systems DESIRE. A flexible, easily adaptable agent architecture results in which, in addition, facilities have been integrated that provide automated support of the agents own maintenance. Therefore, the agent is not only easily adaptable, but it shows ad...

The study of the behaviour of Reaction-Separation processes with Recycle (RSR) becomes relevant for an integrated design and (plantwide) control at the early stages of the conceptual design, so that not only the recycle structure of the flowsheet can be established but also the operability of the system can be assessed. On the other hand, a computer-aided process design relies on the existence ...