IN THE TITLE COMPOUND [SYSTEMATIC NAME: (4R,4aS,7aR,12bS)-3-cyclo-propyl-meth-yl-4a,9-hy-droxy-7-oxo-2,3,4,4a,5,6,7,7a-octa-hydro-1H-4,12-methano-benzofuro[3,2-e]isoquinolin-3-ium bromide methanol monosolvate], C(21)H(26)NO(4) (+)·Br(-)·CH(3)OH, two of the three six-membered rings adopt chair conformations while the third, which contains a C=C double bond, adopts an approximate half-boat confor...

In the crystal of the title salt, C8H10NO2 (+)·Br(-), the bromide anions and the phenylglycinium cations are -linked through N-H⋯Br, O-H⋯Br and C-H⋯O hydrogen bonds, generating sheets lying parallel to (001).

In the cation of the title compound, C(7)H(7)N(2) (+)·Br(-), the nitrile group and the benzene ring are almost coplanar (r.m.s. deviation = 0.0043 Å). In the crystal, the cations and anions are connected by inter-molecular N-H⋯Br hydrogen bonds, forming a two-dimensional network parallel to (010).

In the title compound, C(6)H(7)ClN(+)·Br(-), the amino N atom is protonated. All non-H atoms of the cation are essentially coplanar [r.m.s. deviation = 0.004 (3) Å]. In the crystal, N-H⋯Br hydrogen bonds connect the ions, forming a ribbon-like structure propagating along [010].

In the cation of the title compound, C(7)H(7)N(2) (+)·Br(-), all non-H atoms are essentially coplanar [r.m.s. deviation = 0.010 (5) Å]. The compound is isomorphous with the chloride analogue. In the crystal, the cations and anions are connected by N-H⋯Br hydrogen bonds.

Binding studies of cationic detergents such as cetyltrimethyl ammonium bromide, Cetyl pyridinium bromide and dodecyl trimethyl ammonium bromide with β Lactoglobulin were carried out by equilibrium dialysis, ultraviolet difference and circular dichroism techniques at 25 C. Binding isotherms at pH 5·0, 7·0 and 9·0 show cooperative binding at all concentrations of detergents and the number of avai...