This study was aimed evaluation, Zinc sulfide-chitosan nanoparticles (ZnS-chitosan NPs) as an antibacterial agent. The of were synthesized using a single-step colloidal process. Different factors optimized, which included pH, temperature, reaction time, concentrations chitosan and chloride .The optimal conditions achieved at pH 7, temperature 60℃, time 60min, with 0.04 mg/ml chloride, 2.5 ml 0....

A study of 283 isolates of gram-negative bacilli revealed a good correlation (r = -0.74) between disk diffusion zones of inhibition and agar dilution minimal inhibitory concentrations. Regression analysis suggested that strains with zone sizes =/<11 mm should be considered resistant, but 34 of 45 strains resistant by minimal inhibitory concentration (including 27 strains of Pseudomonas aerugino...

quinazolinone ring system is renown because of its wide spectrum of pharmacological activities due to various substitutions on this ring system. in this study, the minimum inhibitory concentration of the synthesized compounds in our laboratory was determined by micro dilution alamar blue ® assay against six strains of bacteria (three gram-positive and three gram-negative) and three strains of f...

Emergence of drug resistant tuberculosis like multi drug resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and totally drug resistant tuberculosis (TDR-TB) has created a new challenge to fight against these bad bugs of Mycobacterium tuberculosis. Repurposing and revival of the drugs are the new trends/options to combat these worsen situations of tuberculosis in t...

Dairy calves are colonized at a very young age by a multi-drug resistant Escherichia coli (MDR EC) and research studies indicate that the prevalence is not related to recent use of antimicrobials, but that diet and other environmental factors are likely involved. To further investigate the occurrence of this bacterium, we sampled dairy calves on southwestern United States farms at one week of a...

Low concentrations of hemoglobin (0.1 microg./ml. or less) exert a lethal action on some Gram-negative bacteria under certain conditions in vitro. Hemoglobins from various mammals and the distinct genetic types of human hemoglobin all manifest similar bactericidal activity. The bactericidal effect is a function of the globin moiety of the molecule; native and acid or acid-alcohol denatured glob...

Advances in antimicrobial activities of molecule-containing, multiple guanidinium groups against antibiotics-resistant bacteria should be noted. The synthesized polyoctamethylene monoguanidine hydrochloride (POGH), carrying cationic amphiphilic moieties, display excellent activity against multidrug-resistant Pseudomonas aeruginosa (MDR-PA) and other antibiotics-resistant bacteria. The membrane ...

chemical compositions  and antimicrobial effects on E.coli and S.aureus of essential oils from lavandula anguifolia and salvia officinalis were stuied.disk diffusion method was conducted to evaluate the zone of microbial growth inhibition at 1,1:.2,1:.8 and 1:16 dilutions of the essenial oils at four stages of zero(fresh oil).1,2 and 3 months post-exeaction.the antimicrobial effect was also stu...

A series of 1,2,3-trisubstituted indolizines (2a–2f, 3a–3d, and 4a–4c) were screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. Compounds 2b–2d, 4a–4c active H37Rv-MTB strain with minimum inhibitory concentration (MIC) ranging from 4 to 32 µg/mL, whereas 4a–4c, ethyl ester group at 4-position...