PRESENTATION a previously fit 80-year-old woman presented with a 2-week history of spontaneous and extensive bruising affecting all four limbs. The severity was such that she required a transfusion of 8 units of blood. RESULTS OF INVESTIGATIONS a markedly prolonged activated partial thromboplastin time which was only partially corrected with normal plasma; tests for lupus anticoagulant were n...

Acquired hemophilia A (AHA) is a rare bleeding disorder caused by autoantibodies against factor VIII (FVIII). Treatment with clopidogrel is a cause of AHA, but its clinical course is unknown. Recently, we treated a 65-year-old man who was hospitalized for cerebellar infarction and had a prolonged activated partial thromboplastin time (aPTT) with soft tissue oozing after 3 weeks of clopidogrel u...

From the Division of Microbiology and Infectious Diseases (L.C.L.) and the Office of the Director (A.S.F.), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. Address reprint requests to Dr. Lambert at the Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, 6610 Rockledge Dr., Bethesda, MD 2089...

From the National Human Genome Research Institute, National Institutes of Health, Bethesda, MD (L.G.B.); and the Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, and Partners Healthcare Personalized Medicine — all in Boston (R.C.G.). Address reprint requests to Dr. Biesecker at 49 Convent Dr., Rm. 4A56, Bethesda, MD 20892-4472, or at lesb@ma...

White1, J. Li1, W. Liang1, N. Bhagabati1, J. Braisted1, M. Klapa1, T. Currier1, M. Thiagarajan1, A. Sturn1, M. Snuffin2, A. Rezantsev2, D. Popov2, A. Ryltsov2, E. Kostukovich2, I. Borisovsky2, Z. Liu3, A. Vinsavich3, V. Trush3, and J. Quackenbush1,4 1The Institute for Genomic Research, Rockville, MD, 2DataNaut, Bethesda, MD, 3Syntek Systems, Bethesda, MD, and 4Department of Biochemistry, George...

D. Michal FREEDMAN*, Alice SIGURDSON, R. Sowmya RAO, Michael HAUPTMANN, Bruce ALEXANDER, Aparna MOHAN, Michele MORIN DOODY and Martha S. LINET Division of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA Division of Cancer Epidemiology and Genetics, Biostatistics Branch, National Cancer Institute, Bethesda, MD, USA Division of Environ...

From the Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205; Transplantation Research Branch, Casualty Care Research Program Center, Naval Medical Research Institute, Bethesda, Maryland 20814; Instituto de Microbiologia, Universidade Federal de Rio de Janeiro, Ilha do Funddo, Rio de Janeiro 21910, Bra...

Authors’ Affiliations: Women’s Cancer’s Section, Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland Bolder Biopath, Inc., Boulder, Colorado Laboratory Animal Sciences Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland Quin...

From the +Division of Cancer Biology and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, §Section on Biochemistry of Cell Regulation, Laboratory of Biochemical Pharmacology, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205, and 1Centro de Endocrinologia ed Oncologi...

Anand R. Kumar,* Raymond Harshbarger, and Barry Martin Department of Surgery (Plastic Surgery), Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland. Department of Plastic and Reconstructive Surgery, National Naval Medical Center (NNMC), Bethesda, Maryland. Department of Plastic and Reconstructive Surgery, Walter Reed Army Medical Center (WRAMC), Washington, District...