The report by Adamson and colleagues describes a Phase 1 trial in children of 9-cis-RA (1). This report follows by nearly 10 years the report of the pediatric Phase 1 evaluation of ATRA and by more than a decade the initial reports that ATRA induced high remission rates in patients with APL. The authors conclude their report by noting the continuing challenge of identifying the optimal retinoid...

The overexpression of BRF2, a selective subunit RNA polymerase III, has been shown to be crucial in the development several types cancers, including breast cancer and lung squamous cell carcinoma. Predominantly, BRF2 acts as central redox-sensing transcription factor (TF) is involved rescuing oxidative stress (OS)-induced apoptosis. Here, we showed novel link between DNA damage response. Due la...