AIM The aim of this study was to assess the effects of the molecular absorbent recirculating system (MARS) on patients with acute liver failure (ALF) and liver failure with cirrhosis (AoCLF) as well as in cholestatic patients with intractable pruritus in a Mexican population. MATERIAL AND METHODS From August 2003 to December 2011, MARS was used in 38 patients with ALF, 15 patients with AoCLF,...

Fulminant hepatic failure (FHF) is defined by the appearance of severe liver injury with hepatic encephalopathy in a previously healthy person. There are an estimated 2,000 cases of FHF in the United States yearly, representing 0.1% of all deaths and, perhaps, 6% of liver-related deaths. The causes of FHF are many, the chief ones in the United States being hepatitis A; B; non-A, non-B and drug ...

BACKGROUND The outcome of liver transplantation (LT) is influenced by the recipient's clinical condition. In a retrospective observational study, we evaluated the role of pre-LT Molecular Adsorbent Recirculating System (MARS) treatment in improving the clinical status and thereby the outcome of patients with chronic liver disease and severe hepatic decompensation. METHODS Between March 2002 a...

INTRODUCTION Experience with lamivudine treatment for acute severe hepatitis B is limited. Fulminant hepatitis develops in 1% of immunocompetent patients with acute hepatitis B. OBJECTIVE The aim of this study was to evaluate the efficacy of lamivudine in the treatment of severe acute hepatitis B (SAHB) in immunocompetent adult patients. METHODS Between January 2006 and May 2013 at the Clin...

B oth hydrophobic bile salts 2 and unconjugated bilirubin (UCB) induce apoptosis in cultured cells at moderately elevated concentrations and cell necrosis at higher concentrations. Retention of bile salts in cholestasis is believed to cause secondary damage to hepatocytes, and retention of UCB in severe neonatal jaundice is known to cause bilirubin encephalopathy. For both agents, the cytotoxic...

INTRODUCTION Cholestasis leads to liver cell death, fibrosis, cirrhosis, and eventually liver failure. Bile duct ligated rats constitute an interesting model to study the mechanism of cholestasis, and its action on several organs and tissues, including the brain. AIM To analyze brain bile acids individually in ligated rats to evaluate if its profile is altered towards a more toxic condition i...

hyperbilirubinemia is a common problem during neonatal period especially in preterm neonates. transcutaneous bilirubin measurement (tcb) by special devices had been documented as an effective tool for predicting neonatal jaundice in full term neonate, but for preterm infants the present evidences are controversial. we carried out a prospective study in shariati hospital nicu. 126 paired tcb/tot...

OBJECTIVE To evaluate the frequency of recurrence of spontaneous bacterial peritonitis (SBP) in patients with end stage liver disease and the factors responsible for it. STUDY DESIGN Descriptive study. PLACE AND DURATION OF STUDY The Aga Khan University Hospital, Karachi, from November 2008 till November 2009. METHODOLOGY Patients with cirrhosis who were admitted at AKUH with diagnosis of...

Twenty-seven clinical and laboratory data and the subsequent clinical course of 93 consecutive adult patients who underwent orthotopic liver transplantation for various chronic advanced liver diseases were analyzed retrospectively to assess the risk factors of early major bacterial infection and death after the procedure. Forty-one patients (44%) had early major bacterial infection during hospi...

OBJECTIVE: Neonatal hyperbilirubinemia (N-HB) usually resulted in bilirubin encephalopathy even death in children. The present study was designed to investigate the prevention and intervention initiatives for N-HB. MATERIALS AND METHODS: Case-control method was used to study the effects of early intervention on neonate with hyperbilirubinemia and perinatal factors. A total of 412 N-HB cases (20...