The binding data for interaction of a homologous series of n-alkyl sulfates with alkyl chainlengths from C8 to C12 with insulin were analyzed on basis of Hill equation for two classes ofbinding sites .The intrinsic Gibbs free energies were calculated and resolute on basis ofelectrostatic and hydrophobic contributions The estimation of these contributions reveals themajor role of electrostatic i...

the object of this cross sectional study was to determine the hcv subtype 3a envelope protein binding affinity with human leukocyte antigen. envelope 1 (e1) protein is one of the structural proteins responsible for entering the cells through the receptors. the binding affinity of e1 protein epitopes to the selected human leukocyte antigen (hla) class i alleles was investigated using the compute...

this study was carried out to determination of in vitro binding capacity of organic (wheat and barley) and inorganic (perlite) sources for mn, zn, cu, and fe. for this reason wheat and barley were analyzed chemically for moisture, protein, ash, and ether extract, total carbohydrate, ndf, adf, adl, crude fiber, viscosity, cellulose, and total dietary fiber. the in vitro mineral binding capacity ...

introduction: differentiation between infection and sterile inflammation is one of the most difficult medical problems and is relevant in many clinical situations. scintigraphy with radiolabeled antibiotics, еspecially labeled fluoroquinolones, is a promising tool for diagnosing bacterial inflammation. we have attempted to synthesize 99mtc-norfloxacin and studied its properties in experiment. m...

dopamine (da) is one of the main catecholamines in the brain and is crucial for movement coordination, endocrine function, reward, mood, memory and emotions. the dopaminergic system is the primary therapeutic target in the treatment of parkinson’s disease (pd), drug addiction and schizophrenia. notwithstanding, dysfunction of central dopaminergic neurotransmission has also been associated to de...

disposition and transportation of anticancer drugs by human serum albumin (hsa) affects their bioavailability, distribution and elimination. in this study, the interaction of a set of anticancer drugs with hsa was investigated by molecular dynamics and molecular docking simulations. the drugs' activities were analyzed according to their docking scores, binding sites and structural descriptors. ...

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In the present work, the interaction ofFe3O4@CaAl LDH@ Lamivudine with human serum albumin (HSA) was investigated by applying UV–vis and fluorescence spectra. The nanocomposite was quenching the natural fluorescence of HSA, which was indicated the static quenching mechanism. The consequences demonstrated that this nanocomposite can strongly bind to HSA molecules. According to fluorescence quenc...

background: hoxa11 and leukemia inhibitory factor (lif) and basic transcriptional element binding protein1 (bteb1) are expressed in endometrium throughout the menstrual cycle and show a dramatic increase during the mid-luteal phase at the time of implantation. in this case-control study, the expression pattern of these mrna was evaluated in patients with endometriosis at the time of implantatio...