Red clover (RCL) is a perennial plant rich in phytoestrogens (mainly biochanin A, daidzein, genistein and formononetin) which has been used to treat menopausal symptoms, as an alternative to hormone replacement therapy, and to prevent osteoporosis, as well as for prostatic hypertrophy (Ulbricht & Basch, 2005). A critical issue with botanical preparations is their chemical standardization and it...

Inhibition of Aldose Reductase (AR) is very important in terms preventing many diabetic complications such as retinopathy, neuropathy, and cataract. In this study, inhibition effects some antiproliferative agents, which have been shown to biological activities besides their anticancer properties, on the AR enzyme, a diabetes-related were investigated. Biochanin A compound with an IC50 value 4.4...

Isoflavones are secondary phenolic metabolites found in most legumes. These compounds have important pharmacological significance such as anti-osteoporosis, anti-aging, and anti-cancer properties. Breast cancer is one of the common cancers women worldwide. Human epidermal growth factor receptor-2 (HER2) an target breast treatment. In this study, we evaluated ability sixty isoflavones to inhibit...

Mammary tissue differentiation and tumorigenesis were studied in female rats following subcutaneous injection at 2, 4 and 6 days after birth with low or high doses of 17beta-estradiol (0.1 or 10 microg; E2), biochanin A (0.1 or 10 mg; BCA) or bisphenol A (0.1 or 10.0 mg; BPA). Half of the rats were killed on day 35 to analyze the terminal end bud (TEB), terminal duct (TD) and alveolar bud (AB) ...

OBJECTIVE Biochanin A (BCA) is an isoflavone found in red clover and peanuts. Recently, it drew much attention as a promising anticancer and antioxidant. Due to its diversity in pharmacological actions, we were encouraged to investigate its potential as an antifibrotic, elucidating the different molecular mechanisms involved. DESIGN Rats were pretreated with BCA, then injected with carbon tet...