Background: Psoriasis is an immune-mediated, genetic disease manifesting in the skin or joints both, and also has a strong predisposition autoimmune pathogenic traits 1 . The hallmark of psoriasis sustained inflammation that leads to uncontrolled keratinocyte proliferation dysfunctional differentiation. And it’s chronic relapsing disease, which often necessitates long-term therapy 2 Objectives:...

Protein-coding gene families are sets of similar genes with a shared evolutionary origin and, generally, with similar biological functions. In plants, the size and role of gene families has been only partially addressed. However, suitable bioinformatics tools are being developed to cluster the enormous number of sequences currently available in databases. Specifically, comparative genomic datab...

As the emerging field of bioinformatics continues to expand, the ability to rapidly search large databases of genetic information is becoming increasingly important. Databases containing billions of data elements are routinely compared and searched for matching and near-matching patterns. In this paper we explore the use of run-time reconfiguration using field programmable gate arrays (FPGAs) t...

objectives the overall goal of this study was to carry out a set of comparative analyses of arsr gene in plasmid r773 and bacterial chromosome from escherichia coli bl-21(de3). methods pdb and ncbi databases and chimera, mega4, clc main workbench software and 3d-jigsaw and embl-ebi servers were applied to perform this study. by using these software and servers, multiple analyses including deter...

Life sciences research and development has opened up new challenges and opportunities for bioinformatics. The contribution of bioinformatics advances made possible the mapping of the entire human genome and genomes of many other organisms in just over a decade. These discoveries, along with current efforts to determine gene and protein functions, have improved our ability to understand the root...

The volume and complexity of biological data and informations available today need a significant computational data and processes analysis. A huge amount of bioinformatics databases and tools is available. Some of them allow bioinformaticians to intuitively compose their in-silico experiments in the form of workflows. Other applications aim at the analysis, modeling and simulation of biological...

The back-to-back release of the mouse genome and the functionally annotated RIKEN mouse full-length cDNA collection was an important milestone in mammalian genomics. Yet much of the data remain to be explored in terms of biological effects and mechanisms. For example, interspersed repeats account for 39 per cent of the mouse genome sequence and 11 per cent of representative transcripts. A consi...

Mass spectrometry has been widely used for analyses of biomolecules such as proteins. The soft ionization methods available nowadays, the faster and more accurate mass spectrome‐ ters, a diversity of protein databases resulting from large scale genome studies and the ad‐ vances in the bioinformatics field for optimized data mining, altogether significantly contributed to high quality outputs in...

Over last few years, interest on biotechnology has increased dramatically. With the completion of the sequencing of the human genome, such interest is likely to expand even more rapidly. The size of genetic information database doubles every 14 months, overtaxing any existing computational tool for data analysis. There is a persistent and continuous search for new alternatives or new technologi...