the marine environment represents approximately half of the global biodiversity and could provide unlimited biological resources for the production of therapeutic drugs. marine seaweeds comprise few thousands of species representing a considerable part of the littoral biomass. extracts of the cystoseira indica and cystoseira merica were subjected to phytochemical and cytotoxicity evaluation. th...

background : ferulago carduchorum boiss and hausskn belongs to the apiaceae family. this plant grows in west part of iran that local people added it to dairy and oil ghee to delay expiration date and give them a pleasant taste. the aim of this study was to investigate the antioxidant, antimicrobial, acetyl cholinesterase inhibition, cytotoxic, larvicidal activities and composition of essential ...

a quantitative structure–activity relationship (qsar) study is suggested for the prediction of biological activity (pic 50 ) of 3, 4-dihydropyrido [3 ,2-d] pyrimidone derivatives as p38 inhibitors. modeling of the biological activities of compounds of interest as a function of molecular structures was established by means of principal component analysis (pca) and least square support vector mac...

Resveratrol is a polyphenolic flavonoid initially identified as a phytoalexin and as a major constituent of red wine. However interest in this molecule initially developed as a cardioprotective agent and in due course of time therapeutic actions came into limelight. This article explores the different therapeutic activities of Resveratrol and highlights their possible mode of action responsible...

Sapindus emarginatus is important indigenous plant with lots of traditional importance belongs to family sapindaceae. It is commonly called as Soap nut tree which is found in most of the hilly regions of India. Each and every part of the plant is used traditionally in various ailments. Trees of genus Sapindus are cultivated in many parts of India. The secondary metabolites present in Sapindus e...

Quinolones are considered as a big family of multi-faceted drugs; their chemical synthesis is flexible and can be easily adapted to prepare new congeners with rationally devised structures. This is shown by the description of many thousands of derivatives in the literature. Scientists could accurately describe their QSAR, which is essential for effective drug design. This also gave them the cha...

In our course of screening for novel proteasome inhibitors, TMC-95A and its diastereomers, TMC-95Bto D, were isolated from the fermentation broth of Apiospora montagnei Sacc. TC 1093. TMC-95Ainhibited the chymotrypsin-like (ChT-L), trypsin-like (TL), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome with IC50 values of 5.4nM, 200nM, and 60nM, respectively. TMC-95Binhi...