PNAs conjugated to carrier peptides have been employed for the targeting of miRNA precursor, with the aim to develop molecules able to interfere in the pre-miRNA processing. The capability of the molecules to bind pre-miRNA has been tested in vitro by fluorescence assayes on Thiazole Orange labeled molecules and in vivo, in K562 cells, evaluating the amount of miRNA produced after treatment of ...

Single crystals of NiPcI(1.0) (Pc = phthalocyanine), which are composed of one-dimensional stacks of (NiPc)(+0.33) molecules and chains of I(3)(-) molecules, exhibit metallic electrical conductivity in the stacking direction. At room temperature the mean free path of the carrier is 3.3 to 8.2 angstroms.

1. Curcumin is the active ingredient of the dietary spice turmeric and has been consumed for medicinal purposes for thousands of years. Modern science has shown that curcumin modulates various signaling molecules, including inflammatory molecules, transcription factors, enzymes, protein kinases, protein reductases, carrier proteins, cell survival proteins, drug resistance proteins, adhesion mol...

Stimuli-responsive gate mechanisms offer potential for the controlled passage of payload molecules from a porous carrier vehicle on-demand. We describe a method for the enzyme-mediated release of macromolecular guest molecules from inorganic silica particles coated with a bioactive peptide shell, synthesized precisely by Fmoc chemistry. Specific enzymatic hydrolysis of the peptide shell removes...

Chitosan has good biocompatibility, in vivo biodegradability and certain physiological activity, which can be used as a drug carrier to stabilise protect components, causing the promotion of absorption controlling release. Using graphene oxide (GO) cross-linking agent, functional groups its lamellar structure interact effectively with chitosan molecules, leading enhanced mechanical properties o...

micrornas (mirnas) are non-coding small rna molecules with 21–25 nucleotides. it plays significant role in control of gene expression at posttranscriptional/translational level. they are commonly dysregulated in human cancers, whereas they may behave either as oncogenes or as tumor-suppressor genes. both genetic and epigenetic events in deregulation of mirna can lead to cancer development. gene...

This chapter provides a comprehensive overview of state-of-the art research on molecular communication—a molecule-based communication paradigm for biological machines. Unlike current telecommunications based on electric or optical signals, molecular communication exploits biological molecules as information carriers. In molecular communication, senders of communication encode information onto m...

pharmaceutical industry is currently undergoing a transient phase with new orientation. loss of financial resources, presence of new therapeutic agents and increasing cost of research and development have called for a full.scale restructuring within the pharmaceutical industry to retain even the most basic competitiveness. the development of new technologies has been as one way out of the dilem...