Article can be accessed online on: www.ijpsr.com ABSTRACT: The determination of drugs in pharmaceutical preparations and biological fluids is of pivotal importance in the pharmaceutical and medical sciences. Successful analysis requires sensitivities at ppb level or even less in biological fluids with high selectivity and minimal interferences from various artifacts. Till recently, biopharmaceu...

Heroin (3,6-diacetylmorphine) is rapidly hydrolyzed to 6-monoacetylmorphine, which is further hydrolyzed to morphine (1). In this retrospective study, samples of biological fluids were analyzed for free morphine because it is the primary analyte found in biological samples obtained from victims of heroin fatalities (2). Of 1,175 cases reviewed, 29 heroin-induced fatalities were identified. Vict...

The preparation and assessment of a crown ether covalently grafted onto MoS2 as an ion-selective electrode for sodium ions in biological fluids is presented.

The emerging scientific field of proteomics encompasses the identification, characterization, and quantification of the protein content or proteome of whole cells, tissues, or body fluids. The potential for proteomic technologies to identify and quantify novel proteins in the plasma that can function as biomarkers of the presence or severity of clinical disease states holds great promise for cl...

The law of mass action describes reactants as simple ideal fluids of concentrations of uncharged noninteracting particles. Ionic solutions contain interacting charged particles and are not ideal. Interactions of reactants can then be mistaken for complexities in chemical reactions or enzymatic catalysts. The variational theory of complex fluids describes flowing mixtures like biological solutio...

When nanomaterials enter biological fluids, they are immediately covered by biomolecules, particularly proteins, forming the so-called protein corona. The dynamic nature and complexity of the protein corona can impact upon the biological effects and distribution of nanomaterials with an organism. Therefore, the protein corona is an important factor in determining the biological impact of any na...

The surface of superparamagnetic magnetic beads was modified with bisphosphonates to selectively capture calcium phosphate crystals from complex biological fluids (i.e. synovial fluid).

Introduction QuanterixTM has developed a novel platform that en‐ ables the quantification of proteins present in blood and other body fluids at previously undetectable con‐ centrations. The application of this Single Molecule Array (SimoaTM) technology will provide medical researchers with an unprecedented tool for detecting low‐abundance biomarkers and speed the develop‐ ment of a new generati...

The increasing knowledge of the molecular pathogenesis of cancer and the rapid development of new molecular techniques are promoting the study of early molecular alterations involved in cancer development in body fluids. Specific genetic and epigenetic alterations could be found in plasma, serum, and urine cell-free DNA (cfDNA) and could potentially be used as diagnostic biomarkers for several ...

Cell-free circulating microRNAs (miRNAs) in the blood are good diagnostic biomarker candidates for various physiopathological conditions, including cancer, neurodegeneration, diabetes and other diseases. Since their discovery in 2008 as blood biomarkers, the field has expanded rapidly with a number of important findings. Despite the initial optimistic views of their potential for clinical appli...