Most drugs permeate biological membranes via passive diffusion and it is generally assumed that the main barrier is the lipophilic structure of the membrane. However, we have observed that the unstirred water layer adjacent to the membrane surface can in some cases be a barrier just as effective as the lipophilic membrane itself. Hydrophilic cyclodextrins can enhance drug delivery through biolo...

Guided bone regeneration involves excluding non-osteogenic cells from the surrounding soft tissues and allowing osteogenic originating native to inhabit defect. The aim of this work was fabricate, analyze antibiofilm activity evaluate in vivo biological response poly (lactic-co-glycolic acid) (PLGA) electrospun membranes incorporated with tea tree oil furan-2(5H)-one. Samples were exposed Strep...

We report the integration of a complex biological system and a nanoelectronic device, demonstrating that both components retain their functionality while interacting with each other. As the biological system, we use the cell membrane of Halobacterium salinarum. As the nanoelectronic device, we use a nanotube network transistor, which incorporates many individual nanotubes in such a way that ent...

Membrane fusion plays a vital role in several biological processes such as cellular uptake, communication between cells and RNA delivery. Due to its complexity, model membranes minimalistic protein models are often used gain insight into the process. Coiled–coil (CC) peptides, consisting of two five α–helical highly advantageous models. One most common CC complex is formed complementary peptide...

Phospholipid bilayer are the basic structural element of biological membranes. They separate the various cell compartments found in eukaryotic cells and form an outer barrier (cell membrane or plasma membrane) of eukaryotic and prokaryotic cells separating the cytoplasm from the extra-cellular space. The composition of phospholipid bilayers varies with the cell type and function of the membrane...