During the past few years the development of experimental techniques has allowed the quantitative analysis of biological systems ranging from neurobiology and molecular biology. This work focuses on the quantitative description of these systems by means of theoretical and numerical tools ranging from statistical physics to probability theory. This dissertation is divided in three parts, each of...

Investigation of malonyl-CoA:acyl carrier protein transacylase from soybeans has shown that this fatty acid biosynthetic enzyme occurs in at least two isozymic forms. Both forms exist as soluble, low-molecular-mass polypeptides (approx 43 kDa) which catalyze one of the first committed steps in the synthesis of C16 and CIS fatty acids. We have partially purified the two forms of this enzyme from...

The goal of this thesis is to analyze the generation of single unit extracellular action potentials (EAPs), and to explore pertinent issues in the interpretation of EAP recordings. I use the line source approximation to model the EAP produced by individual neurons. I compare simultaneous intracellular and extracellular recordings of CA1 pyramidal neurons in vivo with simulations using the same ...

The article dedicated to the XIV International Conference on Bionics and Applied Biophysics, which took place October 14–15, 2021 in Kyiv (Ukraine).

The role of sidechain packing and native contact interactions in folding: Discontinuous molecular dynamics folding simulations of an all-atom Gō model of fragment B of Staphylococcal protein A Apichart Linhananta and Yaoqi Zhou Department of Physiology and Biophysics, Howard Hughes Medical Institute Center for Single Molecule Biophysics, State University of New York at Buffalo, Buffalo, New Yor...

Cellular Biochemistry and Biophysics Program, Molecular Biology Program, SloanKettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, Department of Biochemical and Analytical Pharmacology, GlaxoSmithKline Inc., Research Triangle Park, NC 27709, Graduate Program in Physiology, Biophysics and Molecular Medicine, Weill Graduate School of Medical Science of Cornell Universi...

1 Cell Biophysics, 3 Protein Phosphorylation Experimental Histopathology Laboratories, Cancer Research UK, London Research Institute, London, UK. 2 Centre Emotion, Hôpital de la Pitié Salpetriere, Paris, France 5 Stanford University School of Medicine, Stanford, USA 6 Cancer Division King’s College London, London, UK 7 Cell Biophysics Laboratory, Unidad de Biofísica (CSIC-UPV/EHU), Sarriena s/n...

Laboratory of Protein and Peptide Drugs, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China. State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China. Center for Biological Imaging, Institute of Biophysics, Chinese Academy...

By 3 4 Christopher B. Ransom, Wucheng Tao , Yuanming Wu, William J. Spain, 5 and George B. Richerson 6 7 Epilepsy Center of Excellence, VA Puget Sound HealthCare System; Dept of 8 Neurology and Dept of Physiology and Biophysics, University of Washington, 9 Seattle, WA; Dept of Neurology and Dept. of Molecular Physiology and 10 Biophysics, University of Iowa, Iowa City, IA 11 12