نتایج جستجو برای: bioreactor

تعداد نتایج: 6462  

2017
Sebastian Schuerlein Thomas Schwarz Steffan Krziminski Sabine Gätzner Anke Hoppensack Ivo Schwedhelm Matthias Schweinlin Heike Walles Jan Hansmann

Tissue Engineering (TE) bears potential to overcome the persistent shortage of donor organs in transplantation medicine. Additionally, TE products are applied as human test systems in pharmaceutical research to close the gap between animal testing and the administration of drugs to human subjects in clinical trials. However, generating a tissue requires complex culture conditions provided by bi...

2014
Xavi Illa Sergi Vila Jose Yeste Carmen Peralta Jordi Gracia-Sancho Rosa Villa

We describe a unique, versatile bioreactor consisting of two plates and a modified commercial porous membrane suitable for in vitro analysis of the liver sinusoid. The modular bioreactor allows i) excellent control of the cell seeding process; ii) cell culture under controlled shear stress stimulus, and; iii) individual analysis of each cell type upon completion of the experiment. The advantage...

2014
Takahiro Yamashita Ryoko Yamamoto-Ikemoto

We investigated the removal of nitrogen and phosphate from the effluent of a sewage treatment plant over a long-term operation in bioreactors packed with different combinations of wood and iron, with a trickling filter packed with foam ceramics for nitrification. The average nitrification rate in the trickling filter was 0.17 kg N/m3∙day and remained at 0.11 kg N/m3∙day even when the water temp...

2003
S. J. HAN B. H. TAN

A gas-liquid-solid inverse  uidization airlift bioreactor was proposed by combining advantages of external-loop airlift reactors and inverse  uidized beds. This airlift bioreactor comprises a gas-liquid riser, a gas separator, a liquid-solid inverse  uidized downcomer and a bottom connector. The effects of the gas velocity and the particle loading on the gas holdup in the riser and the liqui...

2010
Elizabeth Elena Voigt Pavlos P. Vlachos M. Nichole Rylander Cameron D. Tropea Peter F. Pelz

In vitro arterial flow bioreactor systems have been used in tissue engineering as models to investigate the response of endothelial cells to shear. However, the degree to which such models can reproduce physiological flow has not been quantified. Furthermore, previous works have assumed a Poiseuille flow profile for the calculation of wall shear stresses (WSS) experienced by the endothelial lay...

2011
Jaakko Soini Kaisa Ukkonen Peter Neubauer

Bioprocess scale-down simulators are used to investigate the phenomena occurring in industrial scale cultivations. The aim is to simulate the large-scale conditions, characterized by long mixing times introducing local gradients into the bioreactor, in laboratory scale bioreactor. We have expanded the current physiological knowledge about the consequences of such cultivation conditions from wel...

Journal: :Bioresource technology 2008
Habibollah Younesi Ghasem Najafpour Ku Syahidah Ku Ismail Abdul Rahman Mohamed Azlina Harun Kamaruddin

Hydrogen may be considered a potential fuel for the future since it is carbon-free and oxidized to water as a combustion product. Bioconversion of synthesis gas (syngas) to hydrogen was demonstrated in continuous stirred tank bioreactor (CSTBR) utilizing acetate as a carbon source. An anaerobic photosynthetic bacterium, Rhodospirillum rubrum catalyzed water-gas shift reaction which was applied ...

Journal: :Journal of biomedical materials research. Part B, Applied biomaterials 2004
Chih-Hung Chang Feng-Huei Lin Chien-Cheng Lin Cheng-Hung Chou Hwa-Chang Liu

Tissue engineering is a new approach to articular cartilage repair; however, the integration of the engineered cartilage into the host subchondral bone is a major problem in osteochondral injury. The aim of the present work, therefore, was to make a tissue-engineered osteochondral construct from a novel biphasic scaffold in a newly designed double-chamber bioreactor. This bioreactor was designe...

Journal: :Cloning and stem cells 2008
Shuanghong Lü Sheng Liu Wenjun He Cuimi Duan Yanmin Li Zhiqiang Liu Ye Zhang Tong Hao Yanmeng Wang Dexue Li Changyong Wang Shaorong Gao

Autogenic embryonic stem cells established from somatic cell nuclear transfer (SCNT) embryos have been proposed as unlimited cell sources for cell transplantation-based treatment of many genetic and degenerative diseases, which can eliminate the immune rejection that occurs after transplantation. In the present study, pluripotent nuclear transfer ES (NTES) cell lines were successfully establish...

Journal: :World journal of microbiology & biotechnology 2013
Ramsés A Gamboa-Suasnavart Luz D Marín-Palacio José A Martínez-Sotelo Clara Espitia Luis Servín-González Norma A Valdez-Cruz Mauricio A Trujillo-Roldán

Culture conditions in shake flasks affect filamentous Streptomyces lividans morphology, as well the productivity and O-mannosylation of recombinant Ala-Pro-rich O-glycoprotein (known as the 45/47 kDa or APA antigen) from Mycobacterium tuberculosis. In order to scale up from previous reported shake flasks to bioreactor, data from the literature on the effect of agitation on morphology of Strepto...

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