Multiple myeloma, a plasma cell neoplasm, presents most commonly with anemia, hypercalcemia, renal failure, and bone pain. Only few cases of clinical aggressive presentation associated with bleeding were reported in the medical literature. The reported cases included gastrointestinal bleeding and cardiac tamponade. Spontaneous retroperitoneal haemorrhage as initial presentation has not been so ...

The effects of vaginal bleeding during first and second trimester on pregnancy outcomes was assessed in a hospital-based population of 268 non-diabetic women. The group of non-bleeders comprised 173 females whereas, there were 71 females with first and 24 with second trimester bleeding. Fetal loss (abortion) occurred in 34% of first trimester and 25% of second trimester bleeders. Low birth weig...

BACKGROUND This study describes the burden of bleeding oesophageal varices at the main tertiary referral centre in Accra. DESIGN Retrospective design to describe the endoscopic spectrum and review mortality data following acute upper gastro-intestinal bleeding at the Korle-Bu Teaching Hospital. Endoscopic data was reviewed in the Endoscopy Unit between 2007 and 2010. Mortality data was collat...

Patients with bleeding oesophageal varices die from exsanguination or liver failure or a combination of these factors. The development of liver failure is inevitable if bleeding is allowed to continue, and the first aim of treatment must be to stop haemorrhage by the fastest and simplest method available. Unfortunately bleeding tends to recur unless the portal venous pressure can be permanently...

Background: Pseudoaneurysm of right hepatic artery is a rare complication after bile duct injury (BDI) repair. An unidentified rupture pseudoanuerysm will lead to mismanagement this fatal complication. Massive haemorrhage can present and causes high mortalityCase Description: We report 60-year-old female who suffered jaundice massive upper gastrointestinal bleeding two weeks cholodocoduodenosto...

Hyposensitivity to vasopressin is a well documented phenomenon in animals with portal hypertension and patients with cirrhosis subject to haemorrhage. Haemorrhage is associated with the endogenous release of bradykinin, which may subsequently stimulate the formation of nitric oxide (NO). The present study investigated the relative contribution of NO synthase (NOS) isoforms and the role of brady...

There is no documented study to indicate the role of prolonged packing of renal fossa (24 to 48 hours) to control bleeding in life threating haemorrhage following open pyelolithotomy without compromise in the renal functions. On the contrary emergency nephrectomy was performed for intractable bleeding during renal stone surgery in peripheral hospitals. Several studies have shown the usefulness ...

Dabigatran is an oral direct thrombin inhibitor (DTI) licensed for stroke prevention in atrial fibrillation and likely to be soon approved in Europe for treatment of venous thrombosis. Predictable pharmacokinetics and a reduced risk of intracranial haemorrhage do not negate the potential risk of haemorrhage. Unlike warfarin, there is no reversal agent and measurement of the anticoagulant effect...

Th e prevalence is calculated 0.2-0.5%/100.000 although lower numbers are discussed (0.01%) Men are slightly more aff ected than women (1.4:1) [1]. Most patients present with the neurological sequelae of intracranial haemorrhage caused by the AVM (50%), which is a major cause of intracerebral bleeding in younger adults. In 25% patients present with epileptic seizures and in 25% with other sympt...

Coagulation predominant-type coagulopathy such as microthrombosis and macrothrombosis is a well-known recognised complication found in COVID-19 infected critically ill patients. In the context of high incidence thrombotic events patients with COVID-19, supplementation anticoagulant therapy has been routinely recommended shown to reduce mortality. However, type, dose, duration timing not determi...