A few observations and much reasoning leads to error; many observations and a little reasoning to truth.-Alexis Carrell oncerns have been raised about safety of calcium channel blockers in patients with heart failure since their introduction into cardiovascular medicine more than 25 years ago. By inhibiting the influx of calcium into myocardial cells, calcium channel-blocking drugs can depress ...

Tip-of-the-Tongue experiences (TOTs) are often accompanied by incorrect answers (blockers) that come to mind persistently and seem to block recall. According to the blocking hypothesis, blockers cause retrieval difficulty during TOTs. We predicted that delay would allow participants to forget their blockers, and thereby enhance TOT resolution. In Experiment 1 participants were asked trivia ques...

1. Prev ntion of Cardiovascular Events in Patients With Hypertension and CAD 1.1. Antihypertensive Drugs for the Secondary Prevention of Cardiovascular Events in Patients With CAD 1.1.1. Thiazide and ThiazideType Diuretics 1.1.2. β-Blockers 1.1.3. ACE Inhibitors 1.1.4. Angiotensin Receptor Blockers 1.1.5. Aldosterone Antagonists 1.1.6. Calcium Channel Blockers 1.1.7. Direct Renin Inhibitors 2. ...

The effects of H1-receptor blocking agents, pyrilamine, promethazine, and diphenhydramine, on the amplitude and time course of endplate potentials (e.p.ps) were studied in the sartorius muscles of frogs. H1-receptor blockers (10(-5)-10(-4) M) reduced the amplitude of e.p.ps recorded intracellularly without affecting the resting membrane potential. The acetylcholine potential was decreased by pe...

This review continues a series of reviews on the analysis compounds with cardioprotective properties in number biaromatic structures, which include range sodium channel blockers. Among voltage-gated channels, Nav1.5 isoform is most abundant heart. Sodium blockers have historically been called "class I antiarrhythmics". this type, structure mainly late current belonging to Id subclass antiarrhyt...

β blockers are useful in managing angina and reducing mortality after myocardial infarction and in heart failure. They probably reduce cardiovascular events in high risk surgery and retard the progression of atherosclerosis. In younger patients, β blockers should remain first line antihypertensives, together with diuretics, calcium channel blockers, angiotensin converting enzymes, and adrenergi...