OBJECTIVE The aims of this study were to determine in two institutions the frequency of clotted coagulation profile specimens in neonatal patients, the proportion of patients who had the test repeated if the coagulation profile specimen clotted and the number of abnormal results in the tests that were repeated. METHODS The number of neonatal coagulation profiles (i.e. prothrombin time and act...

OBJECTIVES Bee venom (BV) is a complex mixture of proteins and contains proteins such as phospholipase and melittin, which have an effect on blood clotting and blood clots. The mechanism of action of honey bee venom (HBV, Apis mellifera) on human plasma proteins and its anti-thrombotic effect were studied. The purpose of this study was to investigate the anti-coagulation effect of BV and its ef...

There are four hypotheses which have been advanced to explain the pathophysiology of severe and complicated malaria such as cerebral malaria. However, none of them adequately explains all the features of cerebral malaria in man. One such hypotheses is Disseminated Intravascular Coagulation (DIC). To determine whether this condition occurs in patients with uncomplicated malaria, the authors cond...

Mild bleeding disorders are a common reason for a referral to a hematologist and these conditions can be challenging to evaluate. Recent research has highlighted that some bleeding symptoms are quite common in the general population and that there is clinical variability in symptom expression among individuals with defined bleeding problems. Moreover, bleeding risks for many bleeding disorders ...

Increased risk of both cardiovascular disease (CVD) and bleeding has been found in patients with chronic hepatitis C (CHC) infection, and a re-balanced hemostasis has been proposed. The aim of this study was to investigate functional whole blood coagulation and platelet function in CHC infection. The prospective study included 82 patients with CHC infection (39 with advanced liver fibrosis and ...

INTRODUCTION Direct oral anticoagulants (DOACs) are establishing themselves as principle choices for the treatment of a variety of thrombotic disorders. DOACs are also known to affect common coagulation tests which are routinely performed for patients in clinical practice. An understanding of their varied effects is crucial for the appropriate ordering of coagulation tests and their interpretat...

The blood coagulation system of 66 consecutive patients undergoing consecutive liver transplantations was monitored by thrombelastograph and analytic coagulation profile. A poor preoperative coagulation state, decrease in levels of coagulation factors, progressive fibrinolysis, and whole blood clot lysis were observed during the preanhepatic and anhepatic stages of surgery. A further general de...

Guidelines of official societies for diagnosis and therapy of intraoperatively occurring hypocoagulability rely mainly on data of patients receiving whole blood transfusions. They recommend--provided that laboratory evaluation shows deficiency (values>1.5 fold normal)--administration of fresh frozen plasma, cryoprecipitate and platelet concentrates (platelet count<50,000 or <100,000/microl). Th...

Disseminated intravascular coagulation (DIC) is a syndrome characterised by the systemic activation of blood coagulation, which generates intravascular fibrin leading to thrombosis of smalland medium-sized vessels and eventually contributes to organ dysfunction (1). In addition, the consumption of platelets and coagulation factors may predispose patients with DIC to haemorrhagic complications. ...