Background: Lactic acidosis (LA) and severe hyperlactataemia (HL) are infrequent but serious complications of antiretroviral therapy which have been associated with a high fatality rate. Methods: In a multinational retrospective cohort study LA was defined as arterial blood pH <7.35, bicarbonate <20 mmol/l and lactate above normal and HL as confirmed blood lactate >5 mmol/l. Logistic regression...

BACKGROUND Lactic acidosis (LA) and severe hyperlactataemia (HL) are infrequent but serious complications of antiretroviral therapy that have been associated with a high fatality rate. METHODS In a multinational retrospective cohort study, LA was defined as arterial blood pH<7.35, bicarbonate <20 mmol/l and lactate above normal, and HL as confirmed blood lactate >5 mmol/l. Logistic regression...

ISSEKUTZ, B., JR., H. I. MILLER, P. PAUL, AND K. RODAHL. Effect of lactic acid on free fatty acids and glucose oxidation in dogs. Am. J. Physiol. Qog(6): I 137-1144. Ig65.-Palmitate-I-04 or glucose-C14( U) was infused intravenously for 4 hr at a constant rate in unanesthetized dogs with indwelling arterial and venous catheters. 02 uptake and CO2 output were measured. Specific activity of CO2 an...

&#x0D; Near-infrared spectroscopy (NIRS) is a noninvasive method for measuring tissue oxygenation. The allows monitoring perfusion in shock by revealing hemoglobin oxygen saturation (StO2). current study aims to compare oxygenation levels with hemodynamical and lactate patients severe shock. Study encompasses 19 treated intensive care unit (ICU) at Alexandrovska University Hospital. Ten of the ...

Regular physical exercise is broadly recommended by current European and American hypertension guidelines. It remains elusive, however, whether exercise leads to a reduction of blood pressure in resistant hypertension as well. The present randomized controlled trial examines the cardiovascular effects of aerobic exercise on resistant hypertension. Resistant hypertension was defined as a blood p...

BACKGROUND AND AIMS An association of high lactate levels with mortality has been found in adult patients with septic shock. However, there is controversial literature regarding the same in children. The aim of this study was to find the correlation of serum lactate levels in pediatric septic shock with survival. SETTINGS AND DESIGN This was a prospective observational study at PICU of a tert...

Severe sepsis and septic shock are complex syndromes with high mortality that frequently affect ICU patients. Contributions such as the Surviving Sepsis campaign have led to issuing of guidelines for managing these This manuscript aims provide a review state art using systematic resuscitation use vasopressors in patients shock. Using MESH terms Boolean operators, research information was carrie...

We developed a radioimmunoassay for plasma thromboxane B,, the metabolite of the coronary vasoconstrictor thromboxane A,. To see if thromboxane A, is produced during myocardial ischemia, we used atrial pacing to study 14 patients with greater than 75% occlusive coronary artery disease proved by arteriography. Paired samples were taken from the coronary sinus (CS) and an artery (A) for lactate a...

Intracoronary administration of complement component C5a induces transient decreases in coronary blood flow and regional left ventricular segment shortening, associated with intramyocardial granulocyte trapping. We evaluated the influence of a cyclooxygenase inhibitor (acetylsalicylic acid, n = 8) or a thromboxane A2/prostaglandin H2 receptor antagonist (SQ29548, n = 6) on these C5a-induced car...

Regular physical exercise is broadly recommended by current European and American hypertension guidelines. It remains elusive, however, whether exercise leads to a reduction of blood pressure in resistant hypertension as well. The present randomized controlled trial examines the cardiovascular effects of aerobic exercise on resistant hypertension. Resistant hypertension was defined as a blood p...