Background Septicemia is a serious condition in pediatric population which highly depends on immediate diagnosis and treatment in terms of mortality and morbidity rate. Developing adjunctive laboratory tests to help clinicians make appropriate decision is of great priority. In this study we aimed to evaluate the predictive value of each biomarker to find the most valuable one based of which a r...

I N PREVIOUS STUDIES it was demonstrated that transplantation of skin homografts in rabbits elicited a sig ificant degree of immunity towards homologous blood platelets later infused.1’2 This demonstration that blood platelets and skin share antigens in common could not, however, lead directly to the conclusion that blood platelets contain histocompatibility antigens. It is known that transplan...

The dielectrophoresis (DEP) phenomenon is used to separate platelets directly from diluted whole blood in microfluidic channels. By exploiting the fact that platelets are the smallest cell type in blood, we utilize the DEP-activated cell sorter (DACS) device to perform size-based fractionation of blood samples and continuously enrich the platelets in a label-free manner. Cytometry analysis reve...

The serotonin transporter is implicated in the uptake of the vasoconstrictor serotonin from the circulation into the platelets, where 95% of all blood serotonin is stored and released in response to vascular injury. In vivo studies indicated that platelet-derived serotonin mediates liver regeneration after partial hepatectomy. We have recently generated serotonin transporter knockout rats and d...

I T HAS been demonstrated, qualitatively, that the rate of blood coagulation is related to the presence of blood platelets. This relationship has been known to exist in bird blood since the investigations of Delezenne (I). In mammalian blood, however, conflicting data and opinions regarding the role of platelets in coagulation have been published during the past half-century. Only in the past d...

determination of blood compatibility is an important problem in blood contacting devices. in this study, two classes of materials including polyurethane (based on polyethylene glycol and poly tetrametylene oxide) and polyvinyl alcohol samples, with different hydrophilicity properties were synthesized and their physico-chemical properties were compared. water uptake ratio, ftir spectroscopy, and...

BACKGROUND Differences in plasma and whole blood expression microRNAs (miRNAs) in patients with an acute coronary syndrome (ACS) have been determined in both in vitro and in vivo studies. Although most circulating miRNAs are located in the cellular components of whole blood, little is known about the miRNA profiles of whole blood subcomponents, including plasma, platelets and leukocytes in pati...