PCB126 is a dioxin-like polychlorinated biphenyl (PCB) environmental pollutant with a significant impact on human health, as it bioaccumulates and causes severe toxicity. PCB126-induced immune toxicity has been described, although the mechanisms have not been fully elucidated. In this study, an in vivo protocol of PCB126 intoxication into male Wistar rats by intranasal route was used, which has...

In this research work, 2, 4-substituted oxazolone derivatives OXZ-1 to OXZ-5 were screened for antidiabetic activity at 200 and 400 mg/kg b.w. p.o. for 15 days in streptozotocin induced diabetic rats. Acute and sub-acute toxicity studies were performed as per OECD guideline Up and Down Procedure425 and 407. Clinical signs, body weight, hematological, biochemical and histopathological examinatio...

background pomegranate (punica granatum) is a significant source of bioactive compounds. however, its toxicity is not intensively studied. objectives the current study investigated the safety and tolerability of pomegranate peel extract (ppe) in balb/c mice. conclusions the current study showed that ppe had no toxicity and its use is suggested with potential applications against diseases. resul...

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This study was carried out to investigate blood biochemical alteration in albino rats after cypermethrin treatment. Nitrogen contents of blood in the albino rats have been influenced by the amount of cypermethrin used for toxicity in the acute (1d) and sub chronic (7,14and21days) treatment in the present investigation. The free amino acid, total protein, urea, urea nitrogen, uric acid and creat...

Abstract Background Currently, nanotechnology and nanoparticles have quickly emerged gained the attention of scientists due to their massive applications in environmental sectors. However, these silver potentially cause serious effects on terrestrial aquatic organisms. In current study, freshwater fish C. carpio were exposed blood-mediated for toxicity, mortality, bioaccumulation, histological ...

The raw data showed in this article comes from the published research article entitled "Protective effects of Chlorogenic acid in 3-Nitropropionic acid induced toxicity and genotoxicity" Food Chem Toxicol. 2017 May 3. pii: S0278-6915(17)30226-0. DOI:10.1016/j.fct.2017.04.048. [1]. Data illustrates antitoxic and antigenotoxic effects of Chlorogenic acid (CGA) on toxicity and genotoxicity produce...

Pulmonary toxicity is an infrequent but serious adverse event in patients treated with amiodarone. The main problem at present is that we lack the necessary tools to detect this event or predict which patients will develop pulmonary toxicity. Serum Krebs von den Lungen-6 (KL-6) has been previously recognized as a marker for the activity of diffuse interstitial lung disease. We describe a patien...

Nitrate Poisoning Farmers and ranchers depend on the successful combination of livestock and crops. Forage crops, in particular, are important to the producer, but they should be monitored due to plant toxicants that can be a problem. One toxicosis of concern is Nitrate (N03 ) toxicity. Nitrate toxicity of cattle was noted as early as 1895 with corn-stalk poisoning. However, at that time nitrat...

PURPOSE To study a fixed dose (360 mg) of paclitaxel given i.v. over 3 hours to female patients, and to evaluate prospectively the relationships between the following: body surface area and toxicity; body surface area and pharmacokinetics; and pharmacokinetics and toxicity. EXPERIMENTAL DESIGN The eligibility criteria included the following: female sex; solid tumors; no more than one prior ch...