There has been an enormous body of literature published in the last 10 years concerning copper and PrP (prion protein). Despite this, there is still no generally accepted role for copper in the function of PrP or any real consensus as to how and to what affinity copper associates with the protein. The present review attempts to look at all the evidence for the chemistry, co-ordination and affin...

Alkyl-substituted tetra-coordinate organoboronium bisdiketone complexes exhibit dramatic luminescence thermochromism in organic solvents. In glass-forming alcohols, these complexes exhibit a reversible aqua blue to orange-red to greenish yellow luminescence emission colour change upon cooling.

Several new descriptions of colorimetric methods for the determination of blood sugar have been described in recent years (for example, Polis and Sortwell, 1946; Somogyi, 1945; Nelson, 1944; Haslewood and Strookman, 1939). These procedures are all based on the use of alkaline copper reagents and on the production of molybdenum blue by the action of cuprous copper on complex molybdic acid soluti...

Vivid blue inclusions in white whewellite or weddellite, occurring within the medulla of four lichen species growing on copper-bearing rocks, have been identified as the hydrated copper oxalate, moolooite, CUC204. nH20 (n ~ 0.4-0.7), by infrared spectroscopy and X-ray powder diffraction. The mineral is believed to have been formed by reaction between oxalic acid secreted by the lichen and groun...

The reaction between a5RuH2O2+ (a is NH3) and Pseudomonas aeruginosa azurin at pH 7, followed by oxidation, yields a5Ru(His-83)3+-azurin(Cu2+) as the major product. Spectroscopic measurements (UV-visible, CD, EPR, and resonance Raman) indicate that the native structure is maintained in the modified protein. The site of ruthenium binding (His-83) was identified by peptide mapping. The a5RuHis/Cu...

The measurement of combined copper has been used in a number of procedures for the quantitative determination of amino acids and peptides. Pope and Stevens (1) as well as Schroeder, Kay, and Mills (2) determined the combined copper iodometrically. Martin and Mittelmann (3) analyzed for copper with the polarograph. Woiwod (4) used the spectrophotometer to measure the color produced by the reacti...

The electronic absorption, circular dichroism and X-ray absorption spectroscopy of the red copper protein nitrosocyanin is simulated with classical molecular dynamics simulations in conjunction with time-dependent density functional theory (TDDFT) and multireference configuration interaction (MRCI) calculations on the active site, with the remainder of the protein and solvent included via point...