The aims of this study were to (1) determine whether platelet-rich plasma (PRP) could be prepared as a bioactive scaffold capable of endogenous growth factor release for cartilage repair; (2) compare the chondrogenic differentiation ability of mesenchymal stem cells (MSCs) from bone marrow (BMSC) and from adipose (ADSC) seeded within the PRP scaffold; and (3) test the efficacy of ADSC-PRP const...

Objective- Adipose tissue is an appropriate source for isolation of cells with stem-cell–like properties.  In the present long-term study, the effects of the omental adipose-derived nucleated cells (OADNCs) fraction were compared to those of the undifferentiated cultured bone marrow stromal cells (BMSCs) on sciatic nerve regeneration. Design- Experimental in vivo study. Animals- Fift...

Telomerase reverse transcriptase (TERT) vectors were transfected into bone marrow mesen- chymal stem cells (BMSCs) which then cultured and selected to establish TERT-BMSC cell lines whilst sequencing BMSCs TERT-BMSCs via transcriptome in this study explore their regulatory mechanism effect on osteogenic differentiation after TERT ectopic expres- sion sheep BMSCs. After analysing differential ge...

Back ground  Subsequent to spinal cord injury many pathological changes may occur that could lead to inappropriate environment for repair. The Most important of such changes is the death of neurons. Exogenous administration of growth factors that modulate neuronal survival, synaptic plasticity, and neurotransmission has been proposed as a potential therapeutic treatment for SCI. Among these gr...

In the past few decades, titanium and its alloys have been widely used in orthopaedic field. However, because is bioinert lacks antibacterial properties, infection may happen when bacteria attach to implant surfaces form biofilms. It has studied that some naturally existing micron-scale topographies can reduce bacterial attachment such as cicada wings gecko skins. The aim of this vitro study wa...

With the development of global economy and energy supply chain, uncertainty complexity bauxite maritime chain (BMSC) has been further increased. Determining crucial risks improving chain’s resilient capacity based on operation objectives become important, in order to ensure sustainability competitiveness BMSC. This paper combines quality function deployment (QFD), a multi-criteria decision meth...

In the interest of optimizing osteogenesis in in vitro, the present study sought to determine how porcine bone marrow stromal cell (BMSc) would respond to different concentrations of hyaluronan (HY) and its different combinations with dexamethasone (Dex) and recombinant human bone morphogenic protein-2 (rhBMP-2). Cellular proliferation was determined by 3H-thymidine incorporation into DNA at bo...

An in situ fast-forming BMSC-laden Col-PEG/SF hydrogel with short gelation time, great biocompatibility and good mechanical properties was fabricated for cartilage regeneration.

objective(s):oct4 is a transcription factor required for pluripotency during early embryogenesis and the maintenance of identity of embryonic stem cells and pluripotent cells. therefore, the effective expression regulation of this gene is highly critical. utr regions are of great significance to gene regulation. in this study, we aimed to investigate the potential regulatory role played by 5´ut...