A modeling investigation was performed to choose moderator material and size for creating optimal epithermal neutron beams for BNCT based on a proton accelerator and the (7)Li(p,n)(7)Be reaction as a neutrons source. An optimal configuration is suggested for the beam shaping assembly made from polytetrafluoroethylene and magnesium fluorine to be placed on high current IPPE proton accelerator KG...

Fricke gel dosimetry is a valuable method for in-phantom dose measurements in complex irradiation modalities like IMRT and BNCT. Implementation of this dosimetry technique requires dedicated instruments capable of measuring and further analysis immediately in situ at the radiation facility. This work presents a novel and integral dosimetry system aimed to attain portability requirements. The me...

Background: A Boron Neutron Capture Therapy (BNCT) facility, based on a DT neutron generator, with the final goal to find out a potential, alternative, solution to existing BNCT treatment facilities which are based on nuclear reactors is examined. Materials and Methods: With the aim of the MCNP4B Monte Carlo code different beam-shaping assembly (BSA) configurations were considered. Lead was sel...

We have constructed a formal model on cost-benefit of new technology in health care, and apply it on boron neutron capture therapy (BNCT). We assume that the patient health benefit from getting cured in acute treatment is always higher than the patient utility resulting from any long term treatment or death. This assumption makes it possible to evaluate the monetary cost impacts of a new techno...

Boron neutron capture therapy (BNCT), an experimental treatment for certain cancers, destroys only cells near the boron; however, there is a need to develop highly specific delivery agents. As nucleic acid aptamers recognize specific molecular targets, we investigated the influence of boronated nucleotide analogs on RNA function and on the systematic evolution of ligands by exponential enrichme...

Core-polymerized and boron-conjugated micelles (PM micelles) were prepared by free radical copolymerization of a PEG-b-PLA block copolymer bearing an acetal group and a methacryloyl group (acetal-PEG-b-PLA-MA), with 1-(4-vinylbenzyl)-closo-carborane (VB-carborane), and the utility of these micelles as a tumor-targeted boron delivery system was investigated for boron neutron capture therapy (BNC...