Breathing during the first postnatal hours has not been examined in mice, the preferred mammalian species for genetic studies. We used whole body plethysmography to measure ventilation (VE), breath duration (T(TOT)), and tidal volume (VT) in mice delivered vaginally (VD) or by cesarean section (CS). In experiment 1, 101 VD and 100 CS pups aged 1, 6, 12, 24, or 48 h were exposed to 8% CO2 or 10%...

Airway hyperresponsiveness, airway inflammation, and reversible airway obstruction are physiological hallmarks of asthma. These responses are increasingly being studied in murine models of antigen exposure and challenge, using whole body plethysmography to noninvasively assess airway hyperresponsiveness. This approach infrequently has been correlated with indexes of airway hyperresponsiveness m...

a Sección de Neumología Pediátrica y Fibrosis Quística, Hospital Universitario Vall dH́ebron, Barcelona, Spain b Sección de Neumología Pediátrica, Hospital Universitario Donostia, San Sebastián, Guipúzcoa, Spain c Departamento de Pediatría, Facultad de Medicina y Odontología, UPV/EHU, San Sebastián, Spain d Sección de Neumología Pediátrica, Consorci Hospitalari Parc Taulí, Sabadell, Barcelona, S...

BACKGROUND Air-displacement plethysmography (ADP) is becoming a popular method to assess body composition. Several studies have shown certain types of clothing can affect measurements of body density, however no study has specifically investigated the effect of cotton gym shorts and spandex bicycle shorts on body density. METHODS Thirty-seven males (23.0 +/- 3.2 yr., 177.3 +/- 5.4 cm., 74.8 +...

Piirila P1*, Smith HJ2, Hodgson U3 and Sovijärvi AR1 1Unit of Clinical Physiology, Department of Clinical Physiology and Nuclear Medicine, HUS Medical, Imaging Centre, Helsinki University Central Hospital and Helsinki University, Helsinki, Finland 2Research in Respiratory Diagnostics, Bahrendorfer Str. 3, 12555 Berlin, Germany 3Heart and Lung Centre Helsinki, Helsinki University Central Hospita...

introduction: recently a relation between female sex hormones and severity of asthma symptoms has been proposed. as a common endocrine dysfunction, polycystic ovary syndrome (pcos) could significantly influence the level of sex hormones in pcos patients. regarding the possible role of sex hormones in airway physiology, the present study was conducted to survey the effects of pcos on pulmonary f...

Noncalibrated respiratory inductance plethysmography has been used to measure respiratory function by calculation of the phase angle and, more recently, by determination of the ratio of each time to reach peak tidal expiratory flow to total expiratory time (TPEF/TE). Since TPEF/TE is known to be decreased in airway obstruction when derived from flow signals obtained by a pneumotachograph, we wa...

Using the technique of whole body plethysmography, lung mechanics were measured in a group of infants with wheezy bronchitis. Compared with a group of normal infants previously studied, airway resistance and thoracic gas volume were found to be raised. Nebulized salbutamol was then administered and measurements were repeated when it was found that there was no objective improvement. It is concl...

Both human and animal studies have demonstrated that respiratory parameters change in response to presentation of alerting stimuli, as well as during stress, yet central neuronal pathways that mediate such responses remain unknown. The aim of our study was to investigate the involvement of the amygdala in mediating respiratory responses to stressors of various intensities and duration. Adult ma...

Earlier studies report that sinoaortic baroreceptor denervation (SAD) in rats causes moderate elevation of mean arterial pressure along with a marked increase of arterial pressure lability (APL). In this context, we studied the effects of selective aortic denervation (AD) or selective carotid denervation (CD) on the regulation of blood pressure. In addition, we evaluated the effects of selectiv...