Simple and easy methods to evaluate swallowing are required because of the recently increased need of rehabilitation for dysphagia. "Artificial food bolus", but not "artificial food", would be a valuable tool for swallowing evaluation without considering the mastication effect which is altered according to the individual's oral condition. Thus, this study was carried out to fabricate artificial...

•Eptifibatide mediates potent antithrombotic effects when used in primary PCI. •Standard eptifibatide infusion for several hours increases bleeding complications. •A novel, short regimen retains ischemic protection during •Bleeding complications are greatly reduced by the abbreviated regimen. •Avoiding prolonged treatment may improve clinical outcomes. The glycoprotein IIb/IIIa inhibitor eptifi...

There is no randomized study carried out in order to compare their pharmacokinetic parameters although midazolam, as a sedative, has been widely administered via continuous infusion as well as intermittent bolus doses in mechanically ventilated critically ill patients. We prospectively investigated the effect of these two principal methods on pharmacokinetic parameters in 23 of mentioned patien...

Abstract This study evaluated the impact of different gluten-free bread's inner structure on oral processing and texture perception. Four rice-based breads were prepared varying water hydration (H: 85 or 100 g water/100 g flour) fermentation time (F: 30 75 min). Mechanical properties breads, bolus (after three chews at swallowing point), subject's chewing activities, perceived sensations using ...

OBJECTIVES The efficacy of high dose furosemide as a continuous infusion was compared with a bolus injection of equal dose in patients with severe heart failure. BACKGROUND The delivery rate of furosemide into the nephron has been proved to be a determinant of diuretic efficacy in healthy volunteers. METHODS In a randomized crossover study we compared the efficacy of a continuous infusion o...

INTRODUCTION Integrating opioid risk and benefit into a single function may give a useful single measure of the opioid's positive and negative effects. An explorative study on the effects of fentanyl on antinociception and respiratory depression was performed to construct fentanyl risk-benefit (utility) functions. METHODS Twelve volunteers received a 3.5-μg/kg fentanyl intravenous injection o...

Date Approved: [Month dd, yyyy] iii ACKNOWLEDGEMENTS I would like to thank my family, especially my parents, for their continued support for me throughout every phase of my life. In addition I would like to thank my research advisor Dr. Omer T. Inan for allowing me to have the opportunity to research in his lab; I will be forever grateful for the knowledge and experience I have gained during th...

Background CMR techniques are increasingly being used to evaluate myocardial extracellular volume (ECV). In the most commonly applied method, ECV is quantified using haematocrit-adjusted myocardial and blood T1 values measured before and after gadolinium bolus. The technique is based on a two-compartment model, assuming contrast kinetic effects to be negligible due to a dynamic equilibrium betw...

The authors illustrate different endoscopic procedures that may require anaesthesiological assistance through analgo-sedation procedures. Analgo-sedation is useful to the patient and to the endoscopist that can carry out the exam more rapidly and in optimal conditions. The technique employed consists in the administration of propophol, starting with an initial bolus of the drug followed by a co...