background: the aim was to investigate the relationships among lean mass (lm), fat mass (fm), and bone mineral density (bmd) in women stratified by body mass index (bmi) (bmi – normal-weight, overweight, obese) and to determine threshold at which body fat assumes negative relationship with bmd. methods: this was a cross-sectional study in 471 healthy caucasian women, aged 18-67 years. bmd, lm, ...

the relationship between blood physiological attributes and carcass characteristics wasstudied in 40 randomly selected 8-month-old ram lambs of ghezel and mehraban (20 rams per breed)sheep. one day before slaughter, blood samples were obtained after a 24 hr fast. serum samples wereassayed for glucose, cholesterol, serum urea nitrogen (sun), total protein, albumin, triglycerides,creatinine, and ...

BACKGROUND Glycomacropeptide (GMP) is a 64-amino acid glycophosphopeptide released from κ-casein during cheesemaking that promotes satiety, reduces body fat, increases bone mass and infers prebiotic and anti-inflammatory effects. The impact of adiposity and gender on bone health is unclear. OBJECTIVE To determine how feeding female mice diets providing 60% Fat Kcal (high-fat) or 13% Fat Kcal ...

Mesenchymal stem cells (MSCs) are prototypical adult stem cells with the capacity for self-renewal and differentiation with a broad tissue distribution. MSCs not only differentiate into types of cells of mesodermal lineage but also into endodermal and ectodermal lineages such as bone, fat, cartilage and cardiomyocytes, endothelial cells, lung epithelial cells, hepatocytes, neurons, and pancreat...

Gender differences have been described in osteoporosis with females having a higher risk of osteoporosis than males. The differentiation of bone marrow stromal cells (BMSCs) into bone or fat is a critical step for osteoporosis. Here we demonstrated that loss of the androgen receptor (AR) in BMSCs suppressed osteogenesis but promoted adipogenesis. The mechanism dissection studies revealed that A...

Obesity and body fat distribution are important risk factors for the development of type 2 diabetes and metabolic syndrome. Evidence has accumulated that this risk is related to intrinsic differences in behavior of adipocytes in different fat depots. In the current study, we demonstrate that adipocyte precursor cells (APCs) isolated from visceral and subcutaneous white adipose depots of mice ha...

Drug targeting of adult stem cells has been proposed as a strategy for regenerative medicine, but very few drugs are known to target stem cell populations in vivo. Mesenchymal stem/progenitor cells (MSCs) are a multipotent population of cells that can differentiate into muscle, bone, fat, and other cell types in context-specific manners. Bortezomib (Bzb) is a clinically available proteasome inh...