BACKGROUND Bone healing and its reconstruction in fractures, especially in long bones are of particular importance in regenerative medicine. This study compares the bone healing rate after a human xenograft of mineralized bone and together with an allograft of bone marrow mesenchymal stem cells (MSCs) in an experimental tibial bone fracture rabbit model. METHODS In fall 2009, twenty New Zeala...

This study was conducted to evaluate the effects of treatment with strontium ranelate (SR) on the repair of bone defects and molecular components of bones in femurs. Adult female rats (n=27) were subjected to ovariectomy (OVX) or Sham surgery. Thirty days after surgery, a defect was made in the femur and the animals were then divided into three groups: OVX, SHAM and OVX+SR. Euthanasia was perfo...

Critical sized bone defect (CSBD) animal models are used to evaluate and confirm efficacy and potency of new treatment modalities based on bone tissue engineering before the latter can be applied in clinical practice. In this study, a bilateral CSBD model in the iliac wings of sheep is described in detail. To demonstrate that this is a large animal CSBD model in sheep, bone healing within the d...

BACKGROUND In cases with infected non-union, the primary step is eradication of the infection before attempting to achieve union. Release of antibiotics from the bone cement at a high concentration and its penetration to the surrounding tissues, including cortical and cancellous bone, prompted the use of antibiotic cement in the control of bone infection. The aim of this study is to summarize o...

bone has a capability to repair itself when it is fractured. repair involves the generation of intermediatetissues, such as fibrous connective tissue, cartilage and woven bone, before final bone healing can occur. theprocess of cartilage-to-bone transition (cbt) is a key for the achievement of rigid bone healing duringfracture repair. we tested this potential for elastic cartilage using a long ...

Excisional wounds were made in the maxillas and mandibles of rhesus monkeys, and the osseous wound-healing responses at postsurgical intervals ranging from 1 to 28 days were evaluated by light microscopy. The excisional defects were initially filled with a coagulum which was subsequently replaced by granulation tissue emanating from the endosteal tissues. Cortical and trabecular bone forming th...

Rib segment, as one of the most widely used autologous boneresources for bone repair, is commonly isolated with an empty left in the defect. Although defective rib repair is thought to be unnecessary traditionally, it's of vital importance actually to promote rib regeneration for patients with better postoperative recovery and higher life quality. Comparative investigations on rabbit rib bone r...

Background: One of the important criteria for successful treatment of bone defects with calcium phosphate osteoplastic materials is a full-fledged recovery of the biomechanical characteristics of the injured bone. However, the information regarding the effect of β-tricalcium phosphate on the biomechanical dynamics of the healing of the defect compact bone in the scientific literature is not pre...

The current investigation was aimed at identifying the role of mesoporous wollastonite particles on the healing of rat tibial bone defect. The bone defect was created with a 3-mm-diameter dental drill, and it was filled with mesoporous wollastonite particles. After second and fourth weeks of filling treatments, it was found that mesoporous wollastonite particles promoted bone formation as evide...

Introduction: Diagnosis of lesions and bone defects is very important and there is a lack of substantial studies on the most appropriate method for bone defect measurement. Hence, the aim of this study is to evaluate the accuracy of multi-slice computed tomography (MSCT) and cone-beam computed tomography (CBCT) in the diagnosis of mandibular bone defects present in sheep. Material & Methods: T...