RANULOMATOUS LESIONS have been found iii paraffin sections nlade from particles of bone marrow removed by aspiration from patients w’it-h tuberculosis, histoplasmosis, brucehlosis, sarcoidosis, infectious mononucleosis, malignant lymphomas or miscellaneous and indeterminate disorders.19 In a previous paper,4 I discussed the significance of granulomatous lesions foiits(l in sections made from bo...

Human bone marrow is a fascinating and complex organ. Its major function is to produce and sustain normal haemopoiesis, and in a normal adult this entails the production of more than 10 cells/day. The marrow contains most of the multipotent haemopoietic stem cells, and provides an environment for these cells to diVerentiate into each of the well recognised peripheral blood cells (erythroctes, l...

Background Bone marrow and adipose tissue are two main sources of mesenchymal stem cells (MSCs). Some of studies suggest that there are some differences in gene expression profile of MSCs-derived from various tissues. To investigate gene expression profile by qRT-PCR, an appropriate reference gene with stable expression level should be chosen for normalizing data.  This study was designed to e...

introduction: breast cancers in the early phase frequently undergo distant metastasis and survival of patients is greatly dependent on distant metastasis. the occurrence of micrometastasis has been suggested to relate with prognostic features of breast cancer, such as lymph node metastasis and the presence of vascular invasion. the aim of this study was to examine the presence of keratin-19 mrn...

RANULOMATOUS LESIONS have been found iii paraffin sections nlade from particles of bone marrow removed by aspiration from patients w’it-h tuberculosis, histoplasmosis, brucehlosis, sarcoidosis, infectious mononucleosis, malignant lymphomas or miscellaneous and indeterminate disorders.19 In a previous paper,4 I discussed the significance of granulomatous lesions foiits(l in sections made from bo...

A 76-year-old man with symptomatic bone metastases from castrationresistant prostate cancer underwent Radium-223-dichloride (Ra-223) therapy. Before Ra-223 therapy, he had normal peripheral blood cell counts. Ra-223 therapy relieved his shoulder and low back pain. The elevation of the serum prostate-specific antigen (PSA), doubling every month during Ra-223 therapy, suggested a PSA flare or rel...

bone marrow mesenchymal stem cells can differentiate into neurons and astrocytes after transplantation in the spinal cord injury of rats. although bone marrow mesenchymal stem cells are known to protect against spinal cord injury through anti-apoptotic effects, but generation of neural stem cells with large number and safety protocols unclear. in the present study, described the differentiation...

RANULOMATOUS LESIONS have been found iii paraffin sections nlade from particles of bone marrow removed by aspiration from patients w’it-h tuberculosis, histoplasmosis, brucehlosis, sarcoidosis, infectious mononucleosis, malignant lymphomas or miscellaneous and indeterminate disorders.19 In a previous paper,4 I discussed the significance of granulomatous lesions foiits(l in sections made from bo...

Gelatinous bone marrow transformation (GMT), also known as starvation marrow, represents a rare pathological entity of unclear etiology, in which bone marrow histopathology demonstrates hypoplasia, fat atrophy, and gelatinous infiltration. The finding of gelatinous marrow transformation lacks disease specificity; rather, it is an indicator of severe illness and a marker of poor nutritional stat...

The spectrum of plasma cell disorders is broad. Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma are asymptomatic disorders characterized by monoclonal plasma cell proliferation in the bone marrow in the absence of end-organ damage. Waldenström macroglobulinemia typically involves an ontogenically less mature lymphoplasmacytic bone marrow cell and is characteri...