Rheumatoid arthritis is a chronic inflammatory disease with a multifactorial etiology and varied course, which in the majority of patients leads to partial disability or to permanent handicap. Its characteristic trait is a persistent inflammation of the synovial membrane and the formation of an invasive synovial tissue, called the pannus, which in time leads to destruction of the cartilage, sub...

LCH is a disease of abnormal clonal proliferation langerhans cell the bone marrow derived monocyte-macrophage lineage. Cells with characteristic coffee bean / grooved indented nuclei background histiocytes, lymphocytes, eosinophils and other inflammatory cells are seen. Clinical presentation varies from unifocal unisystem to multifocal multisystem. We present rare case multisystem involving hig...

Counting of different classes of white blood cells in bone marrow smears can provide pathologists with valuable information regarding various hematological disorders. For automatic imaging analysis techniques, precise segmentation of White Blood Cells is quite challenging due to the complex contents in bone marrow smears. Far more different from traditional color imaging analysis method, we int...

The standard approach to assess hematopoietic stem cell (HSC) engraftment in experimental bone marrow transplantation models relies on detection of donor hematopoietic cells in host bone marrow following death; this approach provides data from only a single time point after transplantation for each animal. In vivo bioluminescence imaging was therefore explored as a method to gain a dynamic, lon...

osteoarthritis (oa) is a prevalent chronic disease impacting on quality of life and has societal and economical burden increasing with age. yet, no confirmed pharmacological, biological or surgical therapy could prevent the progressive destruction of oa joint. mesenchymal stem cells (mscs) with immunosuppressive activities emerged a potential therapy. we describe a magnetic resonance images (mr...