I T IS well-established that repopulation of hemopoietic tissue occurs in lethally irradiated mice given bone marrow.1 The relation of survival2 and spleen recolonization3 to bone marrow close has been described, as has that of spleen cell dose to antibody production4 in lethally irradiated mice. It is probable that the cell responsible for repopulation of erythropoietic tissue is the stem cell...

Bone marrow stem cells participate in tissue repair processes and may have roles in skin wound repair. Diabetes is characterized by delayed and poor wound healing, and type 1 diabetes seems to lead to stem cell dysfunction. Hence, stem cell dysfunction could contribute to poor healing, and stem cell-based therapies may be efficacious in diabetic wounds. We investigated the potential of exogenou...

arm grooves of star-fish have mesenchymal stem cells derived from adipose tissue cell. widespread studies have shown that stem cells derived from adipose-derived mesenchymal stem cell from bone marrow have many similarities in terms of the ability to differentiate into a variety of tissues. most of the animals live in warm and shallow waters and the waters of this feature is that it is low in d...

The bone marrow niche represents a specialized environment that regulates mesenchymal stem cell quiescence and self-renewal, yet fosters stem cell migration and differentiation upon demand. An in vitro model that embodies these features would open up the ability to perform detailed study of stem cell behavior. In this paper we present a simple bone marrow-like niche model, which comprises of na...

allogeneic bone marrow transplantation is the only definie cure in thalassemia and its most important complication is chronic graft-versus-host disease (cgvhd). we analysed the incidence of cgvhd and its associated risk factors in a group of 89 iranian thalassemic patients of hla-identical sibling transplants surviving at least 90 days after transplantation.in the majority of cases (39) cgvhd o...

Primary bone marrow diffuse large B-cell lymphoma (DLBCL) is a rare type of extranodal lymphoma with poor prognosis. Here, we report a case of primary bone marrow DLBCL successfully treated with high-dose chemotherapy and rescued by in vivo rituximab-purged autologous stem cells. A 39-year-old woman visited our hospital because of anemia. Bone marrow examination revealed a large B-cell lymphoma...

Irradiation induces bone injury by generating free radicals that adversely affect the microenvironment for Mesenchymal stem cells (MSCs) and damages bone marrow blood vessels. We wished to investigate the efficacy of antioxidant administration in protecting stem cell microenvironments and promoting bone marrow vasculature recovery after radiation treatment. The antioxidant ascorbic acid was adm...

BACKGROUND During the resent years there has been interest in using bone marrow stem cells to treat liver cirrhosis. However, there is a potential concern for malignant transformation after stem cell therapy. The aim of this study was to evaluate the development of hepatocellular carcinoma (HCC) after autologous bone marrow stem cell transplantation for liver cirrhosis. METHODS All the patien...

the neoplastic niche comprises complex interactions between multiple cell types and molecules requiring cell-cell signaling as well as local secretion. these niches are important for both the maintenance of cancer stem cells and the induction of neoplastic cells survival and proliferation. each niche contains a population of tumor stem cells supported by a closely associated vascular bed compri...

Background Bone marrow and adipose tissue are two main sources of mesenchymal stem cells (MSCs). Some of studies suggest that there are some differences in gene expression profile of MSCs-derived from various tissues. To investigate gene expression profile by qRT-PCR, an appropriate reference gene with stable expression level should be chosen for normalizing data.  This study was designed to e...