نتایج جستجو برای: bone mineralization
تعداد نتایج: 314895 فیلتر نتایج به سال:
The morphogenetic and differentiation events required for bone formation are orchestrated by diffusible and insoluble factors that are localized within the extracellular matrix. In mice, the deletion of ICAP-1, a modulator of β1 integrin activation, leads to severe defects in osteoblast proliferation, differentiation, and mineralization and to a delay in bone formation. Deposition of fibronecti...
The three-dimensional network of lacunae and canaliculi that regulates metabolism in bone contains osteocytes and their dendritic processes. We constructed a synchrotron radiation X-ray microscope for sequential tomography of mouse tibia first by using a Talbot interferometer to detect the degree of bone mineralization and then by using absorption contrast under a slightly defocused setting to ...
Natural composite biomaterials are good structural supports for bone cells to regenerate lost bone. Here, we report that a chitosan-collagen composite film accelerated osteoblast proliferation, differentiation and matrix mineralization in MC3T3-E1 cells. Intriguingly, we observed that the film enhanced the phosphorylation of Erk1/2. We showed that the chitosan-collagen composite film increased ...
BACKGROUND Vitamin D (VD) and estrogen deficiencies impair Ca absorption and bone mineralization, and the relevance of the interaction between these factors has not been fully understood. AIM OF THE STUDY The aim of the present study was to clarify the effects of a nondigestible saccharide, difructose anhydride III (DFAIII), on the interaction of VD and estrogen deficiencies involved in Ca ma...
Leptin functions through a well-documented central neuroendocrine pathway to regulate bone mass. However, the ability of leptin to modulate bone mass through a peripheral mechanism has been debated due to conflicting in vitro results and lack of sufficient in vivo models. We utilized mice with LoxP sites introduced into the long-form leptin receptor (ObRb) gene to determine how leptin regulates...
Morphometric methods are commonly used in the diagnosis of diseases of bone. These may be divided into static and dynamic measurements. Static measurements include: (i) the proportion of trabecular surface which is resting, resorbing or covered by osteoid (by a perimeter intersect technique); (ii) the thickness of osteoid seams; and (iii) the proportion of the section occupied by mineralized bo...
Materials and Methods Bone mineral content was commonly used as an indicator of mineral adequacy diets of poultry [1]. The major minerals that form the inorganic matrix of bone are calcium and phosphorus [2]. The extent of bone mineralization affects bone strength [2] and poor mineralization leads to increased risk of fractures [3]. Skeletal abnormalities and architectural deterioration of bone...
Context Recessive mutations in TMEM38B cause type XIV osteogenesis imperfecta (OI) by dysregulating intracellular calcium flux. Objectives Clinical and bone material phenotype description and osteoblast differentiation studies. Design and Setting Natural history study in pediatric research centers. Patients Eight patients with type XIV OI. Main Outcome Measures Clinical examinations inc...
BACKGROUND Several agents are available to treat osteoporosis while addressing patient-specific medical needs. Individuals' residual risk to severe fracture may require changes in treatment strategy. Data at osseous cellular and microstructural levels due to a therapy switch between agents with different modes of action are rare. Our study on a series of five consecutively taken bone biopsies f...
The tendons in the turkey leg have specific well-defined areas which become mineralized as the animal ages and they are a thoroughly characterized model system for studying the mineralization process of bone. In this study, nondestructive Raman spectroscopic analysis was used to explore the hypothesis that regions of the turkey tendon that are associated with mineralization exhibit distinct and...
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