BACKGROUND AND PURPOSE Periosteal new bone formation and cortical hyperostosis often suggest an initial diagnosis of bone malignancy or osteomyelitis. In the present study, we investigated the cause of persistent bone hyperostosis in the offspring of two consanguineous parents. METHODS Clinical assessment, imaging, and direct sequencing were used to elucidate the etiology of the condition see...

Overexpression of SGTP and/or MT may contribute to various carcinogenic processes and to resistance to anticancer treatment. The importance of these proteins, although clearly established in solid tumours, has not been fully understood in haematopoietic neoplasm. The aim of this study was to determine the expression of MT and SGTP in the bone marrow of patients with MPD. Twenty paraffin-embedde...

A wide range of diseases may present with radiographic features of osteolysis. Periapical inflammation, cysts and benign tumours, bone malignancies, all of these conditions may show bone resorption on radiograph. Features of the surrounding bone, margins of the lesion, and biological behaviour including tendency to infiltration and root resorption, may represent important criteria for distingui...

Abstract Background Although osteosarcoma remains the most common primary malignant neoplasm in bone pediatric age group, involvement of foot is extremely rare. Case presentation Our case demonstrates what appeared to be a cyst calcaneus at an outside institution after injury ankle. The patient was sent our for further workup where Computed Tomography scan revealed permeative lytic lesion with ...

BACKGROUND Malignant fibrous histiocytoma (MFH) of bone is a rare primary malignant neoplasm. Recent studies indicate a positive correlation between the telomere maintenance mechanism and tumour aggressiveness in sarcomas. This study was undertaken to analyse the clinical significance of telomere factors in primary tumour samples from patients with MFHs of bone. MATERIALS AND METHODS Telomera...

Introduction. Osteoma is a benign, slowly growing, asymptomatic, osteogenic neoplasm. Osteoma of a bone other than the skull and facial bones is extremely rare. An extremely rare case of parosteal osteoma is reported. Case Presentation. A 51-year-old woman presented with a large mass in the left supraclavicular fossa. Radiographs and computed tomography revealed a well-defined, 9 × 6 cm, lobed ...

Adrenal myelolipoma is a rare benign neoplasm of mesenchymal origin composed mature fatty tissue and bone marrow elements. It non-functioning tumor, usually asymptomatic commonly detected incidentally during evaluation for unrelated symptoms; hence, it referred to as an “incidentaloma”. Large myelolipomas can cause mass effects vague abdominal pain, spontaneous tumor rupture with massive hemorr...

Abstract A newly described entity called “calcified chondroid mesenchymal neoplasms” includes neoplasms with variable amounts of calcification and FN1 fusions [Liu et al, Mod Pathol 2021]. We report a case left temporal bone giant cell granuloma-like lesion that also shows an FN1-TEK fusion. Close monitoring MRI images after surgery has showed no recurrence. Case report: 33-year-old male develo...