abstract  background: resection of the distal end of the radius is indicated in the treatment  of locally aggressive primary benign and malignant bone tumors. the aim of this study  was to evaluate the technique of osteoarticular allograft reconstruction of the distal radius after wide excision of a giant-cell tumor.  methods: we analyzed 15 patients retrospectively who had reconstruction of th...

Purpose: To present a clinical case of benign bone tumor rare localization – chondromyxoid fibroma the temporal bone, simulated chronic inflammation. Material and methods: A right is presented. X-ray computed tomography (CT) magnetic resonance imaging (MRI) bones were performed before during hospitalization. Results: Patient T., 29 years old, has been complaining about discomfort, congestion no...

Giant cell tumor (GCT) is a benign primary bone neoplasm that usually occurre in the long bones. The skull is affected in only 1% of cases, predominantly in the sphenoid and temporal bones. Maxillary sinus involvement is exceedingly rare. The case is a 26 year-old man presented with history of gradually increasing swelling in the right side of face without any history of trauma or systemic diso...

OBJECTIVES This study aimed to develop a scoring system to predict the survival time of patients with bone metastases after radiation therapy (RT). The scoring system can guide physicians to a better selection of appropriate treatment regimens. MATERIALS AND METHODS The medical records of 125 patients with bone metastases treated with RT between January 2007 and September 2010 were reviewed r...

Osteoblastic bone metastases are common in prostate and breast cancer patients, but mechanisms by which tumor cells stimulate new bone formation are unclear. We identified three breast cancer cell lines that cause osteoblastic metastases in a mouse model and secrete endothelin-1. Tumor-produced endothelin-1 stimulates new bone formation in vitro and osteoblastic metastases in vivo via the endot...

Blockade of osteoclast (OC) activity efficiently decreases tumor burden as well as associated bone erosion in immune-compromised animals bearing human osteolytic cancers. In this study, we showed that modulation of antitumor T-cell responses alters tumor growth in bone, regardless of OC status, by using genetic and pharmacologic models. PLCγ2(-/-) mice, with dysfunctional OCs and impaired dendr...

A four-year-old male Persian cat was referred with three weeks history of progressive lameness due to a rigid osseous mass with 3.50×2.50×2.00 cm in dimensions in his left arm. In the histopathological evaluation of bone biopsy, two distinct populations of cells including multinucleated giant cells and oval cells which embedded in a fibro-osseous stroma and surrounded by lamellar bone trabecula...

epitheloid osteosarcoma (carcinosarcoma) of the bone is a rare malignant tumor and only a few cases have been reported in the literature. in this study, we report two cases of osseous carcinosarcoma (epitheloid osteosarcoma) with immunohistochemical studies.  the morphological and immunohistochemical data in these two cases support the theory of divergent differentiation of primitive, uncommitt...

a case of a 3-year-old patient with osteolytic lesion in the lumbar region is presented. the clinic-radiological suspicion was infection, primary or metastatic tumor of spine. subsequently, a ct guided biopsy proved an eosinophilic granuloma of bone. following medical treatment after two month, there was improvement in patient medical status.

Blockade of osteoclast (OC) activity efficiently decreases tumor burden as well as associated bone erosion in immune-compromised animals bearing human osteolytic cancers. In this study, we showed that modulation of antitumor T-cell responses alters tumor growth in bone, regardless of OC status, by using genetic and pharmacologic models. PLCg2 / mice, with dysfunctional OCs and impaired dendriti...