We investigated the bone phenotype of mice with generalized lymphoproliferative disorder (gld) due to a defect in the Fas ligand-mediated apoptotic pathway. C57BL/6-gld mice had greater whole body bone mineral density and greater trabecular bone volume than their wild-type controls. gld mice lost 5-fold less trabecular bone and had less osteoclasts on bone surfaces after ovariectomy-induced bon...

Context Recessive mutations in TMEM38B cause type XIV osteogenesis imperfecta (OI) by dysregulating intracellular calcium flux. Objectives Clinical and bone material phenotype description and osteoblast differentiation studies. Design and Setting Natural history study in pediatric research centers. Patients Eight patients with type XIV OI. Main Outcome Measures Clinical examinations inc...

introduction : efforts are being made to improve the efficacy of biomaterials used as bone substitutes for bone regeneration in the oral and maxillofacial region. graft materials have been recently produced in iran; however, studies are required to confirm their efficacy. this study aimed to compare the histomorphometric results of using mineralized allografts produced by the hamanandsaz baft k...

Diabetic osteoporosis is increasingly recognized as a significant comorbidity of type 1 diabetes mellitus. In contrast, type 2 diabetes mellitus is more commonly associated with modest increases in bone mineral density for age. Despite this dichotomy, clinical, in vivo, and in vitro data uniformly support the concept that new bone formation as well as bone microarchitectural integrity are alter...

PURPOSE To determine the changes in stability as a reflection of early healing around single-stage, roughened-surface implants in humans utilizing resonance frequency analysis (RFA). RFA makes use of a transducer, attached to an implant, which is excited over a range of sound frequencies with subsequent response analysis. MATERIALS AND METHODS Twenty patients had 1 to 4 implants placed in the...