Mitochondria from a variety of mouse and rat tumors were studied. In general, tumor mitochondria isolated in a medium containing bovine serum albumin (BSA) exhibit respiratory control, while mitochondria isolated from the same tumor in the absence of BSA lack respiratory control. Some variability in oxidative phosphorylation was obtained among the various types of tumors. The rates of phosphory...

Abstract In this paper, the bovine serum albumin protected gold nanozymes (BSA-Au nanozymes) were utilized as a novel nanodrug for treatment of acute T-type lymphoblastic leukemia (Jurkat) by production excessive ROS and effect on expression anti-apoptotic genes. The BSA-Au Bcl-2 survivin in Jurkat cell line was checked. results showed that genes significantly reduced after with (p-value 0.001)...

The protein adsorption and both its conformational arrangements electrochemical interactions on the surface of metallic biomaterials has an immense impact corrosion/biodegradation biocompatibility implantable metals. In this study, we used scanning Kelvin probe force microscopy (SKPFM) to reveal synergistic effect various bovine serum albumin (BSA) concentrations overpotential conditions BSA me...

Serum albumin protein plays a key role in the transportation and distribution of bioactive species including metal ions metal-based drugs and, therefore, nature their binding could provide important insight for development new drugs. In present investigation, interactions bovine serum (BSA) with three biologically ions: Pt4+, Ir3+ Fe2+ were screened using easy-to-use cost-effective Fourier-Tran...

We have fabricated a terahertz compatible polytetrafluoroethylene (PTFE) based microfluidic flow-cell, in which time-domain spectroscopy of range concentrations aqueous bovine serum albumin (BSA) was performed, demonstrating the device’s suitability for future studies biomolecular interactions. The novel combination oxygen plasma treatments and milling used to both increase decrease wettability...

An optical biosensor for proteomic breast cancer biomarker detection in complex media is presented. Bloch Surface Waves (BSW) excited onto one dimensional photonic crystal (1DPC) were used to probe the interaction of HER2 with three antibody species and an inert protein (Bovine Serum Albumin - BSA). The system combines Label-Free readings track bioassay real-time development Fluorescence emissi...

Various forms of zinc oxide (ZnO) are frequently used in the design optical and electrochemical sensors. However, properties ZnO should be properly adjusted depending on application area. Therefore, this work, we have investigated changing/tuning by depositing a layer polydopamine (PDA) its surface. In order to perform investigation, surface fluorine-doped tin (FTO) was modified with nanorods P...

pH-responsive nanocarrier systems exhibit diverse applications due to their relevance biological where, discrete pH differences are displayed between tissues and cellular compartments. Changes in the physicochemical properties of responsive nanocarriers variations pH, can cause release cargos a targeted controllable manner offering spatiotemporal control. In this study, bovine serum albumin-pol...

It is known that catechins interact with the tryptophan (Trp) residue at the drug-binding site of serum albumin. In this study, we used catechin derivatives to investigate which position of the catechin structure strongly influences the binding affinity against bovine serum albumin (BSA) and human serum albumin (HSA). A docking simulation showed that (-)-epigallocatechin gallate (EGCg) interact...

Serum albumin constitutes 35-50 mg/ml of plasma proteins and performs various physiological activities including the regulation of osmotic pressure on blood, maintaining buffering of the blood pH, carrying different fatty acids and other small molecules, such as bilirubin, hormones, drugs and metal ions, as well as participating in immunological responses. Serum albumin is an extensively used p...