OBJECTIVE Cerebral microbleeds (MBs) have been previously associated with cognitive dysfunction, including Alzheimer's disease. In the present study, we aimed to clarify the relationship between cerebral lobar MBs and the regional cerebral blood flow (CBF). METHODS We investigated the data obtained from 122 patients in our memory clinic who were examined by both MRI and (99m)Tc-ethyl cysteina...

The aim of the present study was to identify alterations in brain function following administration of a single, low-dose of codeine phosphate in healthy volunteers using resting-state functional magnetic resonance imaging (fMRI). In addition, the metabolic changes in the two sides of the frontal lobe were identified using 1H-magnetic resonance spectroscopy (1H-MRS). A total of 20 right-handed ...

To understand temporally extended events, the human brain needs to accumulate information continuously across time. Interruptions that require switching of attention to other event sequences disrupt this process. To reveal neural mechanisms supporting integration of event information, we measured brain activity with functional magnetic resonance imaging (fMRI) from 18 participants while they vi...

A large proportion of the brain is devoted to vision, so it is not surprising that visual processing is commonly affected when the brain is damaged. The classical model of understanding is that image data from the retina are transferred via the optic nerves and lateral geniculate bodies to the occipital cortex where the picture is ‘seen’; and damage to this system leads to loss of visual field ...

Grey matter (GM) of the frontal lobe carries out its complex function such as muscle control, speech, decision making, and self-control; while white (WM) is a major contributor to human brain enlargement higher structural connectivity. This study was conducted assess effect sex age on grey volumes (GMV WMV) gyri in healthy young adult Sudanese. The present included 139 Sudanese subjects (80 mal...

BACKGROUND Posterior Cortical Atrophy (PCA) is a neurodegenerative disease characterized by a progressive decline in selective cognitive functions anatomically referred to occipital, parietal and temporal brain regions, whose diagnosis is rather challenging for clinicians. The aim of this study was to assess, using quantitative Magnetic Resonance Imaging techniques, the pattern of regional grey...

We report a functional neuroimaging study of a 43-year-old woman with Nasu-Hakola disease (NHD). Regional cerebral blood flow (rCBF) images were measured with technetium-99m ethyl cysteinate dimer single photon emission computed tomography (SPECT). rCBF was decreased in the bilateral frontal lobes and thalamus. This finding was consistent with the known underlying neuropathology in patients wit...

We report the case of a patient with Fahr disease presenting with schizophrenia-like psychosis for whom a technetium Tc99 methyl cysteinate dimmer brain study was used to evaluate regional blood flow. A brain single photon-emission CT study showed increased cerebral blood flow to the bilateral temporal lobes. Such perfusion abnormalities may reflect psychotic symptoms, including auditory halluc...

We know much more about the anatomy of the frontal lobes than we do about their functions or how these functions go wrong in schizophrenia. Key areas for brain imaging research that will increase our understanding of frontal function concern (1) long-range functional connectivity and the mechanisms by which one brain region modulates activity in another and (2) the mechanisms underlying specifi...

Paulk AC, Zhou Y, Stratton P, Liu L, van Swinderen B. Multichannel brain recordings in behaving Drosophila reveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation. J Neurophysiol 110: 1703–1721, 2013. First published July 17, 2013; doi:10.1152/jn.00414.2013.—Neural networks in vertebrates exhibit endogenous oscillations that have been associated...