seizure activity has been proposed to result in the generation of reactive oxygen species (ros), which then contribute to seizure-induced neuronal damage and eventually cell death. although the mechanisms of seizure-induced ros generation are unclear, mitochondria and cellular calcium overload have been proposed to have a crucial role. we aim to determine the sources of seizure-induced ros and ...

introduction: there are several different molecular pathways in tissue damage by ischemic brain injury. the use of antioxidants and free radical scavengers are a matter of attention by some researchers. crocus sativus (saffron) is used previously for protective effects in ischemia state by some researchers. to assess pathologic aspects of neuroprotection of saffron in some susceptible brain are...

BACKGROUND Securing high-quality mortality statistics requires systematic evaluation of all trauma deaths. We examined the proportion of trauma patients dying within 30 days from causes not related to the injury and the impact of exclusion of patients dead on arrival on 30-day trauma mortality. We also defined the demographics, injury characteristics, cause of death and time to death in patient...

Childhood trauma due to physical abuse, neglect, or sexual abuse is a serious problem in the United States. Trauma can result in disruption or injury to the developing brain and lead to neurodevelopmental deficits that affect a child's functioning and can result in lifelong problems. Research has provided insight into how early childhood maltreatment affects brain development. This article exam...

trauma is the most common reason in 1-34 years olds. in patient with multiple traumas, the head is the most common involved part. the importance of computed tomography (ct scan) in diagnosis of brain trauma is well established and ct of the brain is a choice method. finding lesion in brain traumatic patient is very important so goal of this study is finding of brain ct scan in traumatic patient...

AIM Secondary brain injury starts after the initial traumatic impact and marked by an increase in the intracellular calcium concentrations.This cascadeeventually results in membrane lipid peroxidation and neuronal cell death. MATERIAL AND METHODS We investigated the neuro-protective effects of nimodipine and melatonin in 38 rats after 6 hours of head trauma using the cortical impact injury mo...

This study characterizes motorcyclists living at Maringá-Paraná-Brazil, who were victims of traffic accidents and were attended in hospitals for trauma treatments. The injured have been characterized according to trauma severity, body regions affected and the body region with the most serious injury, besides identifying possible differences in the quality of life of the victims who developed tr...

animal related injuries as most common causes of human morbidity have different pattern by geographical zones. we aimed to explore the main descriptive epidemiology of animal-related injuries in both rural and urban areas in iran. between 2000 and 2004, we collected the data of all the cases of animal related trauma hospitalized for more than 24 hours in eight cities (tehran, mashhad, ahwaz, sh...

Penetrating craniocerebral trauma is an injury in which a projectile violates the skull but does not exit. The significance of penetrating injuries to the head depends largely on the circumstances of the injury, the velocity of impact, and attributes of the projectile. While most penetrating head injuries are caused by firearms, lower-velocity mechanisms of penetrating brain injury present uniq...

Pediatric abusive head trauma – once commonly known as the shaken baby syndrome – is a form of child abuse that results in traumatic brain injury. The peak incidence of pediatric abusive head trauma appears to be in children between the ages of 2 to 4 months; the exact incidence of this injury is not known. Pediatric abusive head trauma often results in severe and permanent neurological damage,...