Perinatal infection is a major cause of neonatal neurologic morbidity. The goal of this study is to examine the effects of intrauterine infection on hippocampal neurogenesis and self-repair during early developmental stages. The animals were randomly divided into two groups: E. coli infected group and control group. Neurogenesis was examined by incorporation of BrdU, a marker of proliferating c...

In this study, we exposed adult rats to chronic variable stress (CVS) and tested the hypothesis that previous early-life exposure to stress changes the manner in which older subjects respond to aversive conditions. To this end, we analyzed the cytogenic changes in the hippocampus and hippocampal-dependent spatial learning performance. The experiments were performed on 18-month-old male rats div...

OBJECTIVES To examine the influence of deep brain stimulation on hippocampal neurogenesis in an adult rodent model. METHODS Rats were anesthetized and treated for 1 hour with electrical stimulation of the anterior nucleus of the thalamus (AN) or sham surgery. The animals were injected with 5'-bromo-2'-deoxyuridine (BrdU) 1-7 days after surgery and killed 24 hours or 28 days later. The authors...

Hair cells in posthatch chickens regenerate spontaneously through mitosis or the transdifferentiation of supporting cells in response to antibiotic injury. However, how embryonic chicken cochleae respond to antibiotic treatment remains unknown. This study is the first to indicate that unlike hair cells in posthatch chickens, the auditory epithelium was free from antibiotic injury (25-250 mg gen...

The aim of the present study was to explore the in vivo mechanism of sister-chromatid exchange (SCE) induction by 5-azacytidine (5-azaC) in murine bone marrow cells. Experiments were performed to examine SCE induction in response to different doses of 5-azaC as well as several exposures. Additionally, we examined the persistence of SCE induction and the effect of bromodeoxiuridine (BrdU) incorp...

PURPOSE To examine the rabbit corneal epithelial cell proliferation rate after extended wear of disposable or silicone hydrogel contact lenses or prolonged eyelid closure. METHODS One randomly chosen eye of 40 New Zealand White rabbits was assigned to silicone hydrogel contact lens wear (n = 15, SH), disposable hydrogel contact lens wear (n = 6, DH), eyelid suturing (n = 15, SUT), or no inter...

Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disorder in the intestines. Current therapies aim at suppressing inflammation to prevent further damage. However, healing already damaged intestinal epithelia still an unmet medical need. In this regard, epithelial achieved via stem cells (ISCs) that are located crypts. Considering literature reports active vitamin D (1,25[OH]2...