A 44-year-old man with chronic hepatitis C received three courses of interferon (IFN) therapy. HCVgenotype was lb, viral load was 1,200 kcopies/ml and interferon sensitivity determining region (ISDR) was the intermediate type before the 1st IFN therapy. The 1st and 2nd IFN therapies resulted in failure to yield a sustained response. Seven years after from the 1st therapy, viral load had decreas...

Complex Concepts into Basic Concepts Rick Szostak University of Alberta Tory Building, Edmonton, AB, T6G 2H4, Canada [email protected] 780-492-7645; FAX 780-492-3300 ABSTRACT Interdisciplinary communication, and thus the rate of progress in scholarly understanding, would be greatly enhanced if scholars had access to a universal classification of documents or ideas not grounded in particu...

The systemic administration of keratinocyte growth factor (KGF) enhances T-cell lymphopoiesis in normal and bone marrow transplanted mice and exerts protection to thymic stromal cells from cytoablative conditioning and graft-versus-host disease-induced injury. However, little is known regarding KGF’s molecular and cellular mechanisms of action on thymic stromal cells. Here we report that KGF in...

We propose a model for the shear failure of a glued interface between two solid blocks. We model the interface as an array of elastic beams which experience stretching and bending under shear load and break if the two deformation modes exceed randomly distributed breaking thresholds. The two breaking modes can be independent or combined in the form of a von Mises-type breaking criterion. Assumi...

This study was conducted with older adults living in a long-stay institution in the city of Foz do Iguacu, Parana, Brazil with the objective of assessing the influence of muscle strength loss in the risk of falls. The sample consisted of 65 elderly who walk without the aid of support for locomotion, 37 women and 28 men, aged between 67 and 80 years. The risk of falls was assessed through the TU...

Irradiation of salivary glands during radiotherapy treatment of patients with head and neck cancer evokes persistent hyposalivation. This results from depletion of stem cells, which renders the gland incapable of replenishing saliva to produce acinar cells. The aim of this study was to investigate whether it is possible to expand the salivary gland stem/progenitor cell population, thereby preve...

Airway epithelial cells are exposed to environmental toxicants that result in airway injury. Naphthalene (NA) causes site-selective damage to Clara cells in mouse distal airways. N-terminally truncated recombinant human keratinocyte growth factor (DeltaN23-KGF) protects against acute lung injury. The present study investigated whether or not DeltaN23-KGF protects against NA-induced acute Clara ...

Keratinocyte growth factor (KGF) is a critical growth factor in lung development and is a protective agent after lung injury, although the exact mechanisms of this protective effect have not yet been elucidated. Our laboratory has shown that circulating epithelial progenitor cells can traffic to the airway and that they appear to be derived from the bone marrow. On this basis, we hypothesized t...

1Raviraj GA, 2Thomas Rony, 3Dhanraj GA, 4Vishal US Rao 1Reader, Department of Pedodontics, KGF Dental College, KGF, Karnataka, India 2Assistant Professor, Department of ENT, MOSC Medical College, Kolenchery, Kerala, India 3Professor, Department of ENT, Annayya ENT Centre, Bengaluru, Karnataka, India 4Assistant Professor, Department of Head and Neck Surgery, RR Medical College, Bengaluru, Karnat...

[Purpose] The purpose of the present study was to compare the reliability of 2 hand-held dynamometers (HHD-1, 2) with different designs, by performing isometric knee muscle extension measurements two times each. [Subjects] The subjects were 40 young healthy adults. [Methods] The reliability of the measurements was examined using Bland-Altman analysis. [Results] Bland-Altman analysis found a fix...