Objective(s): Breast cancer is the most common type of cancer among women worldwide. This study investigated the expression and clinical significance of activating transcription factor 3 (ATF3) in human breast cancer and its relationship with the clinical outcome of breast cancer.   Materials and Methods : ATF3 expressions were detected in 114 primary breast cancer tissues and ...

abstract: introduction: this study was conducted to determine the outcomes of the project of ‘integration of breast cancer screening and early detection’ into primary health care (phc) system and to detect the incidence rate, mortality rate and the stage of reported breast cancers, during the timeframe of the project in shahre-kord. method: a prospective cohort study was conducted, reviewing me...

glutathione s-transferases (gsts) are encoded by a superfamily of genes and play a role in the detoxification of potential carcinogens. the human gsts are divided into four classes: alpha, mu, pi and theta. previous studies indicated that the absence of the glutathione s-transferase m1 (gstm1) protein correlated with an increased risk of developing some types of cancers. association between spe...

introduction: today, breast cancer is one of the most common causes of mortality and morbidty and also the leading health concern of the world. methods: this research was a descriptive study entitled knowledge, attitude and practice regarding prevention of breast cancer in working women of chaloos city. the sample size of study included 612 women working in governmental centers. the instrument ...

background: full blood count has been shown to predict disease severity and mortality risk in cancer patients. this study aimed to highlight the degree of derangements of full blood count parameters and provide mean values in pre-chemotherapy breast cancer patients compared with apparently normal control subjects.methods: this was an unmatched case-control study among breast cancer patients att...

many factors including genetic, environmental, and acquired are involved in breast cancer development across various societies. among all of these factors in families with a history of breast cancer throughout several generations, genetics, like predisposing genes to develop this disease, should be considered more. early detection of mutation carriers in these genes, in turn, can play an import...

background: the present study was performed to investigate the effects of trace elements particularity se, zn and cu on tumor genesis in breast cancer. methods: the inhibitory effect of se, zn and cu, on telomerase activity was analyzed in human breast tumor tissues and breast cancer (t47d) cells. tissue specimens from 24 women with benign breast disease and 32 women with breast cancer specimen...

background: mdm2 (murine double minute2) is an oncoprotein that inhibits the p53 activity. overexpression of mdm2 gene has been reported in several human tumors. in the present study, we aimed to evaluate the impact of 40-bp insertion/deletion (ins/del) polymorphism on the promoter of mdm2 and susceptibility to breast cancer in a sample of iranian population. methods: this case-control study wa...

this study focused on triple-negative breast cancer (tnbc) that is characterized by the lack of expression of estrogen receptor (er), progesterone receptor (pr), and human epidermal growth factor receptor 2 (her-2). the primary goal of this study was to describe the relation between triple-negative receptor status and survival. this is the first study about triple-negative breast cancer in our ...

background: precise diagnosis of disease risk factors via efficient statistical models is the primary step for reducing the heavy costs of breast cancer, as one of the most highly prevalent cancer throughout the world. therefore, the aim of this study was to present a recently introduced statistical model in order to assess its proficiency for model fitting. methods: the information of 1465 eli...