To examine the effects of dietary fat intake on breast cancer risk, we are conducting a randomized trial of dietary intervention in women with extensive areas of radiologically dense breast tissue on mammography, a risk factor for breast cancer. Early results show that after 2 years on a low-fat, high-carbohydrate diet there is a significant reduction in area of density, particularly in women g...

INTRODUCTION Mammographic density is a strong risk factor for breast cancer and an important determinant of screening sensitivity, but its clinical utility is hampered due to the lack of objective and automated measures. We evaluated the performance of a fully automated volumetric method (Volpara). METHODS A prospective cohort study included 41,102 women attending mammography screening, of wh...

PURPOSE Obesity and breast density are both associated with an increased risk of breast cancer and are potentially modifiable. Weight loss surgery (WLS) causes a significant reduction in the amount of body fat and a decrease in breast cancer risk. The effect of WLS on breast density and its components has not been documented. Here, we analyze the impact of WLS on volumetric breast density (VBD)...

Over the past 2 years, the breast advocacy group known as Are You Dense? has gained recognition through its quest to ensure that women with dense breast tissue have access to early breast cancer diagnosis. Their stated mission is to ensure that women are informed of their breast density, the limitations of mammography in detecting breast cancer in dense breast tissue, and the added risk that de...

BACKGROUND Assessing the volume of mammographic density might more accurately reflect the amount of breast volume at risk of malignant transformation and provide a stronger indication of risk of breast cancer than methods based on qualitative scores or dense breast area. METHODS We prospectively collected mammograms for women undergoing screening mammography. We determined the diagnosis of su...

Some studies have suggested that insulin-like growth factor (IGF) pathway is related to premenopausal breast density, one of the strongest known breast cancer risk factors. This study was designed specifically to test the hypothesis that higher levels of IGF-I and lower levels of IGF-binding protein (IGFBP)-3 are associated with high mammographic breast density among premenopausal but not among...

Mammographic density is strongly associated with breast cancer risk. Inflammation is involved in breast carcinogenesis, perhaps through effects on mammographic density. We evaluated associations between inflammatory markers interleukin-6 (IL-6), tumor necrosis factor-a (TNFa), and C-reactive protein (CRP) and mammographic density among postmenopausal women. Plasma IL-6, TNF-a, and CRP levels we...

Early-life exposures may influence the development of breast cancer. The authors examined the association of childhood and adolescent anthropometric factors, physical activity levels, and diet with adult mammographic breast density, a strong risk factor for breast cancer. Women in the Minnesota Breast Cancer Family Study cohort who had undergone mammograms but had not had breast cancer (n=1,893...

Breast density, defined as the proportion of fibroglandular tissue over the entire breast has been linked with a higher risk of developing breast cancer, in fact it has been suggested that women with a mammographic breast density higher than 75 percent have a four-to six-fold higher risk of developing breast cancer than women with little or no dense tissue. Therefore, automatic methods of measu...

OBJECTIVE To determine the association between serum 25 hydroxyvitamin D levels and percent breast density among asymptomatic premenopausal women. METHODS Hundred asymptomatic, pre-menopausal women who visited the General Surgery Breast Clinic, Patel Hospital, Karachi, Pakistan between 3rd March and 10th November, 2015 were included in this study. The serum 25 (OH)D and calcium levels were me...