نتایج جستجو برای: brucella endocarditis

تعداد نتایج: 21154  

Journal: :Revue scientifique et technique 2013
P Skendros P Boura

Resistance to intracellular bacterial pathogens such as Brucella spp. relies on cell-mediated immunity, which involves activation of the bactericidal mechanisms of antigen-presenting cells (macrophages and dendritic cells) and the subsequent expansion of antigen-specific CD4+ and CD8+ T-cell clones. Brucella antigens induce the production of T helper type 1 (Th1) cytokines, and an adequate Th1 ...

Journal: :FEMS microbiology letters 2015
Xiaowei Peng Hao Dong Qingmin Wu

A total of 129 sRNA candidates were identified in Brucella abortus 2308 in our previous work, and one candidate with potential to regulate expression of hemH gene was further analyzed in this study. We found that the novel sRNA can inhibit the expression of hemH and called it BsrH (Brucella sRNA regulating HemH). The expression level of BsrH was tested in four different stress conditions. A sig...

Journal: :Journal of bacteriology 2004
Gireesh Rajashekara Jeremy D Glasner David A Glover Gary A Splitter

Brucella species are responsible for brucellosis, a worldwide zoonotic disease causing abortion in domestic animals and Malta fever in humans. Based on host preference, the genus is divided into six species. Brucella abortus, B. melitensis, and B. suis are pathogenic to humans, whereas B. ovis and B. neotomae are nonpathogenic to humans and B. canis human infections are rare. Limited genome div...

2017
Elisabeth Lindahl-Rajala Tove Hoffman David Fretin Jacques Godfroid Nosirjon Sattorov Sofia Boqvist Åke Lundkvist Ulf Magnusson

Brucellosis is one of the most common zoonoses globally, and Central Asia remains a Brucella hotspot. The World Health Organization classifies brucellosis as a neglected zoonotic disease that is rarely in the spotlight for research and mainly affects poor, marginalized people. Urban and peri-urban farming is a common practice in many low-income countries, and it increases the incomes of familie...

2013
Carlos A. Rossetti Kenneth L. Drake Prasad Siddavatam Sara D. Lawhon Jairo E. S. Nunes Tamara Gull Sangeeta Khare Robin E. Everts Harris A. Lewin Leslie Garry Adams

Brucella melitensis causes the most severe and acute symptoms of all Brucella species in human beings and infects hosts primarily through the oral route. The epithelium covering domed villi of jejunal-ileal Peyer's patches is an important site of entry for several pathogens, including Brucella. Here, we use the calf ligated ileal loop model to study temporal in vivo Brucella-infected host molec...

Journal: :Infection and immunity 2003
Laurence A Guilloteau Jacques Dornand Antoine Gross Michel Olivier Fabienne Cortade Yves Le Vern Dominique Kerboeuf

Brucella, the causative agent of brucellosis in animals and humans, can survive and proliferate within macrophages. Macrophages mediate mouse resistance to various pathogens through the expression of the Nramp1 gene. The role of this gene in the control of Brucella infection was investigated. When BALB/c mice (Nramp1(s)) and C.CB congenic mice (Nramp1(r)) were infected with Brucella melitensis,...

Journal: :Infection and immunity 1970
D Leong R Diaz K Milner J Rudbach J B Wilson

Hot phenol-water extraction of smooth Brucella abortus and B. melitensis cells yielded a toxic fraction which was recovered from the phenol phase (fraction 5). Chemically, fractions 5 from both Brucella species were lipid-carbohydrate-protein-2 keto-3-deoxyoctulosonic acid complexes which were stable to heat and resistant to Pronase digestion. Electron micrographs of the Brucella toxins were mo...

Journal: :The Journal of the Association of Physicians of India 2003
Y A Gokhale A G Ambardekar A Bhasin M Patil A Tillu Jyoti Kamath

OBJECTIVE 1) To identify patients of brucella spondylitis and sacroiliitis amongst patients of 'infective spondylitis' and 'sacroiliitis', 2) To study clinical and radiographic features and outcome of brucella spondylitis. METHODS We reviewed 21 patients of infective spondylitis and 12 of sacroiliitis attending our hospital between March and September 2000 and followed them to identify patien...

Journal: :Clinical and diagnostic laboratory immunology 2004
Juliana Cassataro Karina Pasquevich Laura Bruno Jorge C Wallach Carlos A Fossati Pablo C Baldi

Group 3 of outer membrane proteins (OMPs) of Brucella includes Omp25 and Omp31, which share 34% identity. Omp25 is highly conserved in Brucella species, and Omp31 is present in all Brucella species, except Brucella abortus. Antibodies to Brucella melitensis Omp31 have been sought only in infected sheep, and Western blotting of sera from infected sheep did not reveal anti-Omp31 reactivity. We ob...

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