نتایج جستجو برای: brunaueremmettteller bet

تعداد نتایج: 8813  

2017
Jung Min Shim Jin S Lee Kirsty E Russell Coen H Wiegman Peter J Barnes David Fear Ian M Adcock Andrew L Durham

AIM BET proteins have been shown to regulate gene expression including inflammatory genes. METHODS In order to investigate the role of the BET proteins in immunoglobulin production we treated the human B-cell line CLNH11.4 and primary human B cells and ozone-exposed mice with BET inhibitors (JQ1 or IBET151). RESULTS Both proliferation and IgG production were reduced by JQ1 in a concentratio...

Journal: :CoRR 2017
Michal Derezinski Dhruv Kumar Mahajan S. Sathiya Keerthi S. V. N. Vishwanathan Markus Weimer

We propose Batch-Expansion Training (BET), a framework for running a batch optimizer on a gradually expanding dataset. As opposed to stochastic approaches, batches do not need to be resampled i.i.d. at every iteration, thus making BET more resource efficient in a distributed setting, and when disk-access is constrained. Moreover, BET can be easily paired with most batch optimizers, does not req...

2017
Jennifer L. Hope Christopher J. Stairiker Panagiota I. Spantidea Donald T. Gracias Alison J. Carey Adam J. Fike Marjan van Meurs Inge Brouwers-Haspels Laurine C. Rijsbergen Joseph A. Fraietta Yvonne M. Mueller Rosemarieke C. Klop Erietta Stelekati E. John Wherry Stefan J. Erkeland Peter D. Katsikis

We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8+ T lymphocytes (CTL) generation and effector memory cell formation, is regulated in CTL by microRNA-155 (miR-155). Importantly, we show that the proliferative effect of miR-155 on CD8+ T cells is mediated by T-bet. T-bet levels in CTL were controlled in vivo by miR-155 ...

2017
Fakhri Hassouneh Nelson Lopez-Sejas Carmen Campos Beatriz Sanchez-Correa Raquel Tarazona Alejandra Pera Rafael Solana

The differential impact of ageing and cytomegalovirus (CMV) latent infection on human T-cell subsets remains to some extent controversial. The purpose of this study was to analyse the expression of the transcription factors T-bet and Eomes and CD57 on CD4+, CD4hiCD8lo and CD8+ T-cell subsets in healthy individuals, stratified by age and CMV serostatus. The percentage of CD4+ T-cells expressing ...

Journal: :Molecular medicine reports 2012
Xueni Liu Zhenghao Tang Yi Zhang Jianjun Hu Dan Li Guoqing Zang Yongsheng Yu

Chronic hepatitis B virus (HBV) infection is commonly considered to occur as a result of disturbance of the immune system. T-box expressed in T cells (T-bet) is an essential transcription factor for T helper (Th) cell differentiation and function. The aim of this study was to investigate the effect of T-bet overexpression on Th cell differentiation and the possible mechanism in chronic hepatiti...

2015
Ryan Lenhart Stefan Kirov Heshani Desilva Jian Cao Ming Lei Kathy Johnston Russell Peterson Liang Schweizer Ashok Purandare Petra Ross-Macdonald Craig Fairchild Tai Wong Susan Wee

Running Title: ASCL1 is a target gene of the BET inhibitor JQ1 in SCLC Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Abstract: The BET (bromondomain and extra-terminal) proteins bind acetylated histones and recruit protein complexes to promote transcription elongation. In hematological cancers, BET proteins have been shown to regulate expr...

2016
Thi Hiep Nguyen Steven Maltby Fiona Eyers Paul S. Foster Ming Yang

BACKGROUND Exacerbations of asthma are linked to significant decline in lung function and are often poorly controlled by corticosteroid treatment. Clinical investigations indicate that viral and bacterial infections play crucial roles in the onset of steroid-resistant inflammation and airways hyperresponsiveness (AHR) that are hallmark features of exacerbations. We have previously shown that in...

Journal: :Journal of virology 2005
Rebecca A Russell Heather L Wiegand Michael D Moore Alexandra Schäfer Myra O McClure Bryan R Cullen

Foamy viruses are a family of complex retroviruses that establish common, productive infections in a wide range of nonhuman primates. In contrast, humans appear nonpermissive for foamy virus replication, although zoonotic infections do occur. Here we have analyzed the ability of primate and mouse APOBEC3G proteins to inhibit the infectivity of primate foamy virus (PFV) virions produced in their...

2010
William E. Howden

Elusive bugs (EB) are not reliably discovered using standard methods such as black and white box testing. Bounded exhaustive testing (BET) is a promising approach for their detection. A generic EB fault model is introduced which is used to consider the adequacy of BET for EB detection. BET requires the use of an automatic oracle. Situations in which automation may only be practical with the use...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Antonios O Aliprantis Jingsong Wang John W Fathman Raphael Lemaire David M Dorfman Robert Lafyatis Laurie H Glimcher

Tissue remodeling with fibrosis is a predominant pathophysiological mechanism of many human diseases. Systemic sclerosis is a rare, often lethal, disorder of unknown etiology manifested by dermal fibrosis (scleroderma) and excessive connective tissue deposition in internal organs. Currently, there are no available antifibrotic therapeutics, a reflection of our lack of understanding of this proc...

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