Studies bearing on the lipids of tumors have been made in most cases either with regard to the changes of the lipid content of the blood of tumor animals and patients or the relation between the lipids and the growth of the tumors. Of the lipids, cholesterol has been most frequently studied. Roffo (1) reported that cholesterol is concerned with the development of experimental tumors and that an...

In the Buchwald-Hartwig reaction between HIPTBr (HIPT = 3,5-(2,4,6-i-Pr3C6H2)2C6H3 = hexaisopropylterphenyl) and (H2NCH2CH2)3N, it is possible to obtain a 65% isolated yield of (HIPTNHCH2CH2)2NCH2CH2NH2. A second coupling then can be carried out to yield a variety of "hybrid" ligands, (HIPTNHCH2CH2)2NCH2CH2NHAr, where Ar = 3,5-Me2C6H3, 3,5-(CF3)2C6H3, 3,5-(MeO)2C6H3, 3,5-Me2NC5H3, 3,5-Ph2NC5H3,...

Chapter 1. Suzuki-Miyaura coupling reactions of aryl and heteroaryl halides with aryl-, heteroaryl and vinyl boronic acids proceed in very good to excellent yield with the use of 2-(2',6'-dimethoxybiphenyl)dicyclohexylphosphine, SPhos. Additionally, a comparison of the reactions with SPhos and with 2(2',4',6'-triisoprocpylbiphenyl)-diphenylphosphine is presented that is informative in determini...

Among the motor system disorders the clinician is called upon to treat perhaps one of the most challenging and frustrating is still the condition described as Parkinson's disease. Although advances continue in both the medical and surgical aspects of therapy (Cooper, 1956; Doshay, 1954; Meyers, 1942; Spiegel and Wycis, 1958), the exact mechanism responsible for the benefit in each case remains ...

including atherectomy, endarterectomy, and vein or synthetic bypass grafting. These procedures all have in common an element of injury and a subsequent response of the vascular wall to that injury. The accumulation of vascular smooth muscle cells and associated matrix invariably accounts for the bulk of the intimal hyperplastic lesion. For this reason, clinical investigators have focused on pha...