Fixed drug eruption (FDE) usually appears as a solitary/small number of pruritic, well circumscribed, erythematous--violaceous macules that evolve into oedematous plaques which typically resolve after the discontinuation of the offending drug, leaving residual hyperpigmentation. This eruption is considered pathognomonic of a drug-induced dermatosis and is triggered within a few minutes or up to...

vious to the onset of lesions; therefore they scratched their skin. We observed that these patients presented more lesions and that they were more disseminated than in those patients without pruritus. What is more relevant, in patients 2, 3 and 4 some of the lesions had a linear, Koebner-like, arrangement (Figure 1B). Strikingly, patient 3 developed new lesions on the stitches at the site of bi...

The aims of this study were to determine whether perceived sense of direction was associated with the driving space of older drivers and whether the association was different between genders. Participants (1,425 drivers aged 67-87 years) underwent a battery of visual and cognitive tests and completed various questionnaires. Sense of direction was assessed using the Santa Barbara Sense of Direct...

In this article we study the simultaneous estimation of the means in J-way multiplicative models and a decomposable model for three-way layouts. The estimators which improve on the maximum likelihood estimators under the normalized squared error losses are provided for each model. The proposed estimators correspond to the ones by Clevenson and Zidek[2], Tsui and Press[11] and Chou[1].

A thermally enhanced pump-and-treatment method for pentachlorophenol (PCP)-contaminated soil and groundwater has shown potential advantages over the traditional pump-and-treatment method. Studies on the desorption kinetics of PCP from aquifer soil are the first step toward quantitative assessment of the newly proposed method. Five series of desorption batch tests were conducted at different tem...