Current available data on snake bites in Nepal are based solely on hospital statistics. This community-based study aimed at evaluating the impact of snake bites and determining the risk factors associated with a fatal outcome in southeastern Nepal. A total of 1,817 households, selected by a random proportionate sampling method, were visited by trained field workers in five villages. Extensive d...

The morbidity and mortality associated with snake bite is a serious health concerned especially in developing countries. The rural communities are the worst affected and where it is considered as one of the occupational health hazards especially related to agriculture industry. About 50,000 deaths are recorded per year as a result of snakebite. The scenario may sometimes deteriorate further bec...

Preferential localization of Bkm (Banded krait minor-satellite) DNA sequences on Y/W chromosomes of higher eukaryotes, which remain highly condensed in somatic cells but undergo extensive decondensation in the germ cells during early stages of development, led to the postulation for the existence of a sex- and tissue-specific Bkm-binding protein (BBP). Accordingly, we purified and characterized...

In vitro antivenom efficacy studies were compared to rodent lethality studies to test two Indian snake antivenoms (VINS and BHARAT) against four Sri Lankan snakes. In vitro efficacy was tested at venom concentrations consistent with human envenoming. Efficacy was compared statistically for one batch from each manufacturer where multiple vials were available. In binding studies EC50 for all VINS...

The mouse Y chromosome remains highly condensed in all somatic tissues but decondenses extensively in testis. We have isolated a mouse Y chromosome-specific repeat M34 (11.5 kb) and shown that this is distributed along the Y chromosome except the sex-determining region (the Y short arm) in which GATA repeats are predominantly concentrated. It has 32 copies of GATA repeats in a 2.7 kb fragment. ...

Snake venoms are rich sources of biologically active proteins and polypeptides. Three-finger toxins are non-enzymatic proteins present in elapid (cobras, kraits, mambas and sea snakes) and colubrid venoms. These proteins contain four conserved disulfide bonds in the core to maintain the three-finger folds. Although all three-finger toxins have similar fold, their biological activities are diffe...

TuERii has long been needed a really authoritative and reliable snake-bite poster for use in hospitals, dispensaries, and public institutions in India. At the suggestion of Messrs. Thacker, Spink and Co., a large coloured snake-bite poster, 3| by 2-| feet in size, has now been prepared at the Calcutta School of Tropical Medicine; to be issued as a supplement on payment to subscribers to the Ind...

Abstract Background A comprehensive evaluation of the -omic profiles venom is important for understanding potential function and evolution snake venom. Here, we conducted an integrated multi-omics-analysis to unveil venom-transcriptomic venomic in a same group spine-bellied sea snakes ( Hydrophis curtus ) from South China Sea, where widespread species might generate regionally-specific potentia...