Although stimulatory (feedforward) and inhibitory (feedback) dynamics jointly control neurohormone secretion, the factors that supervise feedback restraint are poorly understood. To parse the regulation of growth hormone (GH) escape from negative feedback, 25 healthy men and women were studied eight times each during an experimental GH feedback clamp. The clamp comprised combined bolus infusion...

Although piano playing is a highly skilled task, basic features of motor pattern generation may be shared across tasks involving fine movements, such as handling coins, fingering food, or using a touch screen. The scripted and sequential nature of piano playing offered the opportunity to quantify the neuromuscular basis of coarticulation, i.e., the manner in which the muscle activation for one ...

The CCD magnitudes in Cousins R photometric passbands are determined for GRB 000926 afterglow ∼ 2.6 day after trigger of the γ−ray burst. Optical light curves of the afterglow emission are obtained by combining the present measurements with the published ones in B and R passbands. They show a steepening of the flux decay as expected of an anisotropic fireball losing collimation with the fall of...

Orexins (hypocretins) play a crucial role in arousal, feeding, and endocrine function. We previously reported that orexin-B activated respiratory neurons in the isolated brainstem-spinal cords of neonatal rats. We herein determined whether orexin-B antagonized respiratory depression induced by sevoflurane, propofol, or remifentanil. We recorded C4 nerve bursts as an index of inspiratory activit...

We have examined extracellularly the firing pattern of neurons in the cat external cuneate nucleus and in the human main cuneate nucleus, focusing upon both the spontaneous firing patterns and its modification by natural stimulation. Many of these neurons exhibit stereotyped doublet or burst firing patterns, e .g., the interval between the spikes might be 1 .0 + 0 .1 msec in a given cell . For ...

The transient X-ray source SAX J1810.8-2609 was discovered on 1998, March 10 with the Wide Field Cameras on board the BeppoSAX satellite, while observing the Galactic Bulge in the 2-28 keV energy range. On March 11, a strong type-I X-ray burst was detected with evidence of photospheric radius expansion. A follow-up target of opportunity observation with the Narrow-Field Instruments (NFI) was pe...

Automatic and accurate detection of the closure-burst transition events of stops and affricates serves many applications in speech processing. A temporal measure named the plosion index is proposed to detect such events, which are characterized by an abrupt increase in energy. Using the maxima of the pitch-synchronous normalized cross correlation as an additional temporal feature, a rule-based ...

Aims. We present broad band optical afterglow observations of a long duration GRB 060124 using the 1.04-m Sampurnanand Telescope at ARIES, Nainital and the 2.01-m HCT at IAO, Hanle, including the earliest ground based observations in R band for this GRB. We determine the decay slope of the light curve at different bands and examine the reality of a proposed jet break. Methods. We use data from ...

BACKGROUND Local field potentials may allow a more precise analysis of the brain electrical activity than the electroencephalogram. In this study, local field potentials were recorded in the thalamocortical axis of rats to (i) compare the performance of several indexes of anesthetic depth and (ii) investigate the existence of thalamocortical correlated or disrupted activity during isoflurane st...