نتایج جستجو برای: buthionin sulfoximine
تعداد نتایج: 1253 فیلتر نتایج به سال:
L-Methionine-DL-sulfoximine, a glutamate analog known to inhibit glutamine synthetase (GS) and glutamate synthase (GOGAT), allowed nitrogenase biosynthesis by Fratikia strain D11 in presence of NH4$. GS activity, detected in cell-free extracts of D1 1 , was higher in N2-fixing than in nonfixing conditions. These facts suggested that nitrogenase biosynthesis in Frankia was probably regulated by ...
Selective inhibition of exclusively transcription-regulating PTEFb/CDK9 is a promising new approach in cancer therapy. Starting from lead compound BAY-958, lead optimization efforts strictly focusing on kinase selectivity, physicochemical and DMPK properties finally led to the identification of the orally available clinical candidate atuveciclib (BAY 1143572). Structurally characterized by an u...
Sulfoximines have gained considerable recognition as an important structural motif in drug discovery of late. In particular, the clinical kinase inhibitors for the treatment of cancer, roniciclib (pan-CDK inhibitor), BAY 1143572 (P-TEFb inhibitor), and AZD 6738 (ATR inhibitor), have recently drawn considerable attention. Whilst the interest in this underrepresented functional group in drug disc...
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